2013 Fiscal Year Final Research Report
The novel fat-derived hormone as a therapeutic target for acute coronary syndrome
| Project/Area Number |
24659384
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
OUCHI NORIYUKI 名古屋大学, 医学(系)研究科(研究院), 寄附講座教授 (00595514)
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| Co-Investigator(Kenkyū-buntansha) |
OHASHI Koji 名古屋大学, 医学系研究科, 寄附講座助教 (10595515)
SHIBATA Rei 名古屋大学, 医学系研究科, 特任講師 (70343689)
MUROHARA Toyoaki 名古屋大学, 医学系研究科, 教授 (90299503)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 分子心臓病態学 / 急性冠症候群 |
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| Research Abstract |
Here, we investigated the impacts of the fat-derived hormone omentin on acute myocardial injury in animal models of ischemia/reperfusion (I/R). We found that systemic administration of human omentin protein to mice reduced myocardial infarct size and apoptosis following I/R. Furthermore, intracoronary injection of omentin improved cardiac injury and dysfunction in a pig model of I/R. Thus, omentin represents a novel target molecule for the treatment of acute coronary syndrome.
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[Journal Article] Transcriptional regulation of an insulin-sensitizing adipokine adipolin/CTRP12 in adipocytes by Krüppel-like factor 152013
Author(s)
Enomoto T, Ohashi K, Shibata R, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Miyabe M, Matsuo K, Joki Y, Hayakawa S, Hiramatsu-Ito M, Ito M, Murohara T, Ouchi N.
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Journal Title
PLoS One
Volume: 8(12)
Pages: e83183
DOI
Peer Reviewed
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[Journal Article] Adiponectin-mediated modulation of lymphatic vessel formation and lymphedema2013
Author(s)
Shimizu Y, Shibata R, Ishii M, Ohashi K, Kambara T, Uemura Y, Yuasa D, Kataoka Y, Kihara S, Murohara T, Ouchi N.
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Journal Title
J Am Heart Assoc
Volume: 2
Pages: e000438
DOI
Peer Reviewed
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[Journal Article] Therapeutic Reendothelialization by Induced Pluripotent Stem Cells After Vascular Injury2013
Author(s)
Yamamoto T, Shibata R, Ishii M, Kanemura N, Kito T, Suzuki H, Miyake H, Maeda K, Tanigawa T, Ouchi N, Murohara T.
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Journal Title
Arterioscler Thromb Vasc Biol
Volume: 33
Pages: 2218-21
DOI
Peer Reviewed
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[Journal Article] iPS cell sheets created by a novel magnetite tissue engineering method for reparative angiogenesis2013
Author(s)
Kito T, Shibata R, Ishii M, Suzuki H, Himeno T, Kataoka Y, Yamamura Y, Yamamoto T, Nishio N, Ito S, Numaguchi Y, Tanigawa T, Yamashita JK, Ouchi N, Honda H, Isobe K, Murohara T.
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Journal Title
Sci Rep
Volume: 3
Pages: 1418
DOI
Peer Reviewed
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[Journal Article] Adipose-derived factor CTRP9 attenuates vascular smooth muscle cell proliferation and neointimal formation2013
Author(s)
Uemura Y, Shibata R, Ohashi K, Enomoto T, Kambara T, Yamamoto T, Ogura Y, Yuasa D, Joki Y, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N.
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Journal Title
FASEB J
Volume: 27
Pages: 25-33
DOI
Peer Reviewed
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[Journal Article] Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical animal models2012
Author(s)
Ogura Y, Ouchi N, Ohashi K, Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, Enomoto T, Uemura Y, Miyabe M, Ishii M, Yamamoto T, Shimizu Y, Walsh K, Murohara T.
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Journal Title
Circulation
Volume: 126
Pages: 1728-38
DOI
Peer Reviewed
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[Journal Article] CTRP9 protects against myocardial injury following ischemia-reperfusion through AMPK-dependent mechanism2012
Author(s)
Kambara T, Ohashi K, Shibata R, Ogura Y, Maruyama S, Enomoto T, Uemura Y, Shimizu Y, Yuasa D, Matsuo K, Miyabe M, Kataoka Y, Murohara T, Ouchi N.
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Journal Title
J Biol Chem
Volume: 287
Pages: 18965-73
DOI
Peer Reviewed
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