2013 Fiscal Year Final Research Report
Significance of reciprocal expression of myocardian and MRTF-A during the development of vascular disease
| Project/Area Number |
24659386
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Circulatory organs internal medicine
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
KUWAHARA Koichiro 京都大学, 医学(系)研究科(研究院), 講師 (30402887)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 分子血管病態学 / 転写調節 |
|---|
| Research Abstract |
Expression of myocardin-related transcription factor (MRTF)-A, a Rho signaling-responsive co-activator of serum response factor (SRF), was found to be increased in injured arteries and to be involved in the increase in proliferation and migration capacity in undifferentiated, activated vascular smooth muscle cells. Moreover, the MRTF-A inhibitor CCG1423 significantly reduced neointima formation following vascular injury in mice. MRTF-A could thus be a novel therapeutic target for the treatment of vascular diseases.
|
Research Products
(40 results)
-
[Journal Article] The Effects of Super-Flux (High Performance) Dialyzer on Plasma Glycosylated Pro-B-Type Natriuretic Peptide (proBNP) and Glycosylated N-Terminal proBNP in End-Stage Renal Disease Patients on Dialysis2014
Author(s)
Nakagawa Y, Nishikimi T, Kuwahara K, Yasuno S, Kinoshita H, Kuwabara Y, Nakao K, Minami T, Yamada C, Ueshima K, Ikeda Y, Okamoto H, Horii K, Nagata K, Kangawa K, Minamino N, Nakao K.
-
Journal Title
PLoS One
Volume: 9(3)
Pages: e92314
-
[Journal Article] Identification of Chemicals Inducing Cardiomyocyte Proliferation in Developmental Stage-Specific Manner with Pluripotent Stem Cells2013
Author(s)
Uosaki H, Magadum A, Seo K, Fukushima H, Takeuchi A, Nakagawa Y, Moyes KW, Narazaki G, Kuwahara K, Laflamme M, Matsuoka S, Nakatsuji N, Nakao K, Kwon C, Kass DA, Engel FB, Yamashita JK.
-
Journal Title
Circ Cardiovasc Genet
Volume: 6(6)
Pages: 624-33
-
-
[Journal Article] Angiotensin II Type 1a receptor signaling directly contributes to the increased arrhythmogenicity in cardiac hypertrophy2013
Author(s)
Yasuno S, Kuwahara K, Kinoshita H, Yamada C, Nakagawa Y, Usami S, Kuwabara Y, Ueshima K, Harada M, Nishikimi T, Nakao K.
-
Journal Title
Br J Pharmacol
Volume: 170(7)
Pages: 1384-95
-
-
[Journal Article] Increased Expression of HCN Channels in the Ventricular Myocardium Contributes to Enhanced Arrhythmicity in Mouse Failing Hearts2013
Author(s)
Kuwabara Y, Kuwahara K, Takano M, Kinoshita H, Arai Y, Yasuno S, Nakagawa Y, Igata S, Usami S, Minami T, Yamada Y, Nakao K, Yamada C, Shibata J, Nishikimi T, Ueshima K, Nakao K.
-
Journal Title
J Am Heart Assoc
Volume: 2(3)
Pages: e000150
-
[Journal Article] Cardiac nuclear High Mobility Group Box 1 prevents the development of cardiac hypertrophy and heart failure2013
Author(s)
Funayama A, Shishido T, Netsu S, Narumi T, Kadowaki S, Takahashi H, Miyamoto T, Watanabe T, Woo CH, Abe JI, Kuwahara K, Nakao K, Takeishi Y, Kubota I.
-
Journal Title
Cardiovasc Res
Volume: 99(4)
Pages: 657-64
-
[Journal Article] Direct Immunochemiluminescent Assay for proBNP and Total BNP in Human Plasma proBNP and Total BNP Levels in Normal and Heart Failure2013
Author(s)
Nishikimi T, Okamoto H, Nakamura M, Ogawa N, Horii K, Nagata K, Nakagawa Y, Kinoshita H, Yamada C, Nakao K, Minami T, Kuwabara Y, Kuwahara K, Masuda I, Kangawa K, Minamino N, Nakao K.
-
Journal Title
PLoS One
Volume: 8(1)
Pages: e53233
-
-
-
[Journal Article] Determination of the B-type Natriuretic Peptide Level as a Criterion for Abnormalities in Japanese Individuals in Routine Clinical Practice : The J-ABS Multi-center Study (Japan Abnormal BNP Standard)2013
Author(s)
Kawai M, Yoshimura M, Harada M, Mizuno Y, Hiramitsu S, Shimizu M, Shoda T, Kuwahara K, Miyagishima K, Ueshima K, Nakao K.
-
Journal Title
Intern Med
Volume: 52(2)
Pages: 171-7
-
-
-
[Journal Article] Reciprocal expression of MRTF-A and myocardin is crucial for pathological vascular remodeling in mice2012
Author(s)
Minami T, Kuwahara K, Nakagawa Y, Takaoka M, Kinoshita H, Nakao K, Kuwabara Y, Yamada Y, Yamada C, Shibata J, Usami S, Yasuno S, Nishikimi T, Ueshima K, Sata M, Nakano H, Seno T, Kawahito Y, Sobue K, Kimura A, Nagai R and Nakao K.
-
Journal Title
EMBO J
Volume: 31(23)
Pages: 4428-40
-
-
-
-
-
-
[Presentation] Impact of C-type Natriuretic Peptide Derived from Vascular Endothelial Cells on Blood Pressure2013
Author(s)
Kazuhiro Nakao, Koichiro Kuwahara, Toshio Nishikimi, Yasuaki Nakagawa, Satoru Usami, Hideyuki Kinoshita, Takeya Minami, Yoshihiro Kuwabara, Chinatsu Yamada, Yuko Yamada, Takeshi Tokudome, Yoko M. Nakao, Shinji Yasuno, Kenji Kangawa
Organizer
第36回日本高血圧学会
Place of Presentation
大阪
Year and Date
20131024-26
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] N-Type Ca2+ Channel Blockade Prevents Sudden Death in Mice with Heart Failure2012
Author(s)
Yuko Yamada, Koichiro Kuwahara, Hideyuki Kinoshita, Yoshihiro Kuwabara, Yasuaki Nakagawa, Chinatsu Yamada, Takeya Minami, Shinji Yasuno, Kazuhiro Nakao, Toshio Nishikimi, Kenji Ueshima, Yasuo Mori, Wataru Shimizu, Kenji Kangawa, Kazuwa Nakao
Organizer
第29回国際心臓研究学会(ISHR)日本部会
Place of Presentation
福岡
Year and Date
20121026-27
-
-
-
-
-
