2013 Fiscal Year Final Research Report
Elucidation of molecular bases for phenotypical modification of dilated cardiomyopathy by environmental factors
| Project/Area Number |
24659390
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | The University of Tokyo (2013)
Osaka University (2012) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOMURO Issei 東京大学, 医学系研究科, 教授 (30260483)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 分子心臓病態学 / モデルマウス / 心不全 / 不整脈 |
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| Research Abstract |
As animal models for dilated cardiomyopathy (DCM), we analyzed the knock-in mice in which a deletion of 3 base pairs coding for K210 in cardiac troponin (TNNT2) found in familial dilated cardiomyopathy (DCM) patients was introduced into endogenous genes. Although mice homozygous for TNNT2 mutant allele (TNNT2 delta210/delta210) exhibited progressive left ventricular chamber dilatation and systolic dysfunction and died due to heart failure, mice heterozygous for TNNT2 mutant allele (TNNT2 delta210/+) did not show the cardiomyopathic phenotype. In TNNT2 delta210/+ mice, the left ventricular systolic function and the arrythmogenicity of ventricular tachycardia/fibrillation were not influenced by high salt intake or high-fat and high-sucrose diet. These results suggest that dietary environment exerts marginal effects on cardiomyopathic phenotype in DCM model mice with the TNNT2 mutation.
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Author(s)
Yoshizawa T, Sakurai T, Kamiyoshi A, Ichikawa-Shindo Y, Kawate H, Iesato Y, Koyama T, Uetake R, Yang,L, Yamauchi A, Tanaka M, Toriyama Y, Igarashi K, Nakada T, Kashihara T, Yamada M, Kawakami H, Nakanishi H, Taguchi R, Nakanishi T, Akazawa H, Shindo T.
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Journal Title
Hypertension
Volume: 61
Pages: 341-351
Peer Reviewed
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Author(s)
Ozasa Y, Akazawa H, Qin Y, Tateno K, Ito K, Kudo-Sakamoto Y, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Minamino T, Nagai T, Kobayashi Y, Komuro I.
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Journal Title
Hypertens Res
Volume: 36
Pages: 859-865
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[Journal Article] High incidence of Aggregatibacter actinomycetemcomitans infection in patients with cerebral infarction and diabetic renal failure : A cross-sectional study2013
Author(s)
Murakami M, Suzuki J, Yamazaki S, Ikezoe M, Matsushima R, Ashigaki N, Aoyama N, Kobayashi N, Wakayama K, Akazawa H, Komuro I, Izumi Y, Isobe M.
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Journal Title
BMC Infect Dis
Volume: 13
Pages: 557
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[Journal Article] Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes2012
Author(s)
Naito AT, Sumida T, Nomura S, Liu ML, Higo T, Nakagawa A, Okada K, Sakai T, Hashimoto A, Hara Y, Shimizu I, Zhu W, Toko H, Katada A, Akazawa H, Oka T, Lee JK, Minamino T, Nagai T, Walsh K, Kikuchi A, Matsumoto M, Botto M, Shiojima I, Komuro I.
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Journal Title
Cell
Volume: 149
Pages: 1298-1313
Peer Reviewed
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