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2012 Fiscal Year Final Research Report

The role of sarcomere-specific isoform of docking protein Gab1in heart failure

Research Project

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Project/Area Number 24659391
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Circulatory organs internal medicine
Research InstitutionOsaka University

Principal Investigator

NAKAOKA Yoshikazu  大阪大学, 医学系研究科, 助教 (90393214)

Co-Investigator(Renkei-kenkyūsha) KOMURO Issei  東京大学, 医学系研究科, 教授 (30260483)
Project Period (FY) 2012
KeywordsGab1 / ドッキングタンパク質 / neuregulin-1 / サルコメア / アイソフォーム
Research Abstract

We are focusing on the role of Gab docking proteins in the cardiovascular field. In the present study, we identified a novel isoformof Gab1 (120 kDa) expressed exclusively in cardiac muscle and skeletal muscle, which is different from a ubiquitous isoform of Gab1 expressed in all the tissues. We succeeded in cloning of sarcomere-specific Gab1 isoform cDNA and found the existence of extra-exon in sarcomere-specific Gab1 isoform in mammals. RT-PCR analysis revealed that the expression of this extra-exon was confined to myocardium and skeletal muscle in mice. In addition, we created rabbit polyclonal antibody specific to the amino acid sequences of this extra-exon, and found that this isoform is indeed expressed in the embryonic murine heart at E12.5.

  • Research Products

    (20 results)

All 2013 2012 Other

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (11 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Gab docking proteins in cardiovascular disease, cancer, and inflammation2013

    • Author(s)
      Nakaoka Y.
    • Journal Title

      International Journal of Inflammation 2012 Article ID 141068

      Pages: e1-e11

    • Peer Reviewed
  • [Journal Article] 大型血管炎-高安病を中心に2013

    • Author(s)
      中岡良和
    • Journal Title

      臨床検査

      Volume: 57 Pages: 298-305

  • [Journal Article] Endothelial Gab1 Deletion Accelerates Angiotensin II-Dependent Vascular Inflammation andAtherosclerosis in Apolipoprotein E Knockout Mice2012

    • Author(s)
      Higuchi K
    • Journal Title

      Circulation Journal

      Volume: 76 Pages: 2031-2040

    • Peer Reviewed
  • [Journal Article] Alpha-synuclein elicits glucose uptake and utilization in adipocytes through the Gab1/PI3K/Akttransduction pathway2012

    • Author(s)
      Rodriguez-Araujo G
    • Journal Title

      Cellular and Molecular Life Sciences

      Volume: 70 Pages: 1123-1133

    • Peer Reviewed
  • [Journal Article] 血管体性幹細胞2012

    • Author(s)
      中岡良和
    • Journal Title

      BioClinica

      Volume: 27 Pages: 844-848

  • [Journal Article] トラスツズマブの心毒性から明らかにされたNeuregulin-1/ErbBシグナルの重要性2012

    • Author(s)
      中岡良和
    • Journal Title

      心臓

      Volume: 44 Pages: 698-699

  • [Journal Article] 高安動脈炎の治療2012

    • Author(s)
      中岡良和
    • Journal Title

      日本臨床(増刊号 血管炎)

      Volume: 71 Supple 1 Pages: 173-178

  • [Presentation] Blockade of Interleukin-6 (IL-6) signaling by Anti-IL-6 Receptor Monoclonal Antibody might be aPromising Therapeutic Strategy for Pulmonary Arterial Hypertension2013

    • Author(s)
      Nakaoka Y
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      20130315-17
  • [Presentation] Angiopoietin-1 Derived fromcardiomyocytes is Essential for Coronary Vein Formation through Attraction of Tie2-positive Endothelial Cells from Sinus Venosus.2013

    • Author(s)
      Arita Y
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      20130315-17
  • [Presentation] Blockaede of interleukin-6 signaling might be a promising therapeutic option for pulmonary arterial hypertension via regulating macrophage polarization.2013

    • Author(s)
      Hashimoto-Kataoka T
    • Organizer
      第77回日本循環器学会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      20130315-17
  • [Presentation] Tocilizumab Ameliorates Vascular Inflammation and Clinical Symptoms in the Patients with TakayasuArteritis Refractory to Glucocorticoids2013

    • Author(s)
      Nakaoka Y
    • Organizer
      American College of Cardiology (ACC) 2013
    • Place of Presentation
      米国カリフォルニア州サンフランシスコ
    • Year and Date
      20130309-11
  • [Presentation] Angiopoietin-1 is essential for coronary vein formation in the developing heart2012

    • Author(s)
      Arita Y
    • Organizer
      第20回日本血管生物医学会 YIA competition
    • Place of Presentation
      徳島、あわぎんホール
    • Year and Date
      20121205-07
  • [Presentation] Angiopoietin-1 is essential for coronary vein formation in the developing heart2012

    • Author(s)
      Arita Y
    • Organizer
      American Heart Association Scientific Session 2012
    • Place of Presentation
      米国カリフォルニア州ロサンゼルス
    • Year and Date
      20121104-07
  • [Presentation] 低酸素誘発性肺高血圧マウスに対するIL-6受容体拮抗薬の発症抑制効果2012

    • Author(s)
      橋本崇弘
    • Organizer
      第3回Molecular Cardiovascular Conference II
    • Place of Presentation
      キロロホテルピアノ
    • Year and Date
      20120907-09
  • [Presentation] アンジオポイエチン1の冠静脈の特異化及び遊走における役割2012

    • Author(s)
      有田陽
    • Organizer
      第3回Molecular Cardiovascular Conference II
    • Place of Presentation
      キロロホテルピアノ
    • Year and Date
      20120907-09
  • [Presentation] Angiopoietin-1 is critical for coronary venogenesis in the developing heart2012

    • Author(s)
      Arita Y
    • Organizer
      17th International Vascular Biology Meeting 2012
    • Place of Presentation
      Wiesbaden, Germany
    • Year and Date
      20120602-05
  • [Presentation] ENdothelial Gab1 deletion accelerates angiotensin II-dependent vascular inflammation andatherosclerosis in apolipoprotein E knockout mice2012

    • Author(s)
      Nakaoka Y
    • Organizer
      17th International Vascular Biology Meeting 2012
    • Place of Presentation
      Wiesbaden, Germany
    • Year and Date
      20120602-05
  • [Presentation] 低酸素誘発性肺高血圧マウスに対するIL-6受容体拮抗薬の発症抑制効果

    • Author(s)
      片岡崇弘
    • Organizer
      第1回肺循環学会
    • Place of Presentation
      東京ステーションコンファレンス
  • [Book] 血管新生研究の最先端2013

    • Author(s)
      中岡良和
    • Publisher
      医薬ジャーナル社
  • [Remarks] ホームページ

    • URL

      http://www.med.osaka-u.ac.jp/pub/cardiology/27research/2784res.html

URL: 

Published: 2014-08-29   Modified: 2014-10-21  

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