Metastasis initiating cell of lung cancer brain metastases

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659403
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Kanazawa University
• Principal Investigator: KITA Kenji 金沢大学, がん進展制御研究所, 助手 (80625252)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肺がん / 脳転移

Outline of Final Research Achievements

We transfected eGFP and luciferase genes into human cancer cell lines, including lung cancer cells, and established in vivo imaging model of brain metastasis (brain tumor) with these cells by intracranial inoculation. These cancer cells produced various angiogenesis-related molecules, but there was no correlation between tumorigenecity in the brain and angiogenesis-related molecules. In the in vivo imaging model, anti-VEGF antibody did not inhibit tumor progression of VEGF-high producing cancer cells. These results suggest that brain metastasis may be regulated multiple factors in addition to VEGF-induced angiogenesis.

Free Research Field

医歯薬学