2013 Fiscal Year Final Research Report
Mechanisms for systemic inflammation in COPD
| Project/Area Number |
24659405
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Tetsuya 高知大学, 教育研究部医療学系, 准教授 (30274377)
IKEZOE Takayuki 高知大学, 教育研究部医療学系, 講師 (80294833)
OHNISHI Hiroshi 高知大学, 教育研究部医療学系, 助教 (90553876)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | COPD / 併存症 / 内臓脂肪 / 全身性炎症 |
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| Research Abstract |
We collected visceral fat tissues (n=120) during abdominal surgery for mainly early abdominal malignancies and investigated inflammatory cells including macrophages and cytokines. The COPD group having obstructive ventilatory impairment and smoking history did not have significantly increased number of macrophages which is a marker for fat tissue inflammation, when compared to non-smokers or healthy smokers. Further, in the COPD group with high serum CRP tended to have higher visceral fat macrophages than those with low CRP, but did not reach to be significant. In the entire study, both BMI and %VC were significantly correlated with the number of visceral fat macrophages independently by multivariate analysis. These results suggest that visceral fat inflammation is not involved in systemic inflammation of COPD, but is associated with lower lung volume.
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Research Products
(22 results)
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[Journal Article] Increased perios tin associates with greater airflow l imitation in patients receiving inhal ed corticosteroids2013
Author(s)
Kanemitsu Y, Matsumoto H, Izuhara K, Tohda Y, Kita H, Horiguchi T, Kuwaba ra K,Tomii K, Otsuka K, Fujimura M, O hkura N, Tomita K, Yokoyama A, Ohnish i H, Nakano Y, Oguma T, Hozawa S, Nag asaki T, Ito I, Oguma T, Inoue H, Taj iri T, Iwata T, Izuhara Y, Ono J, Oht a S, Tamar i M, Hirota T, Yokoyama T, Niimi A, Mishima M.
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Journal Title
J Allergy Clin Im munol
Volume: 132
Pages: 305-312
DOI
Peer Reviewed
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[Journal Article] Different MUC1 gene polymorphisms in German and Japa nese ethnicities affect serum KL-6 le vels2012
Author(s)
Horimasu Y, Hattori N, Ishikawa N, K awase S, Tanaka S, Yoshioka K, Yokoya ma A, Kohno N, Bonella F, Guzman J, O hshimo S, Costabel U.
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Journal Title
Respir Med
Volume: 106
Pages: 1756-64
DOI
Peer Reviewed
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