2013 Fiscal Year Final Research Report
Role of ADP ribosyl cyclase in pathogenesis of preeclampsia
| Project/Area Number |
24659409
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SATO Hiroshi 東北大学, 大学院薬学研究科, 教授 (60215829)
SATO Emiko 東北大学, 大学院薬学研究科, 助教 (20466543)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 高血圧 / 蛋白尿 / 妊娠 / 流産 / 子宮内胎児発育不全 |
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| Research Abstract |
Pre-eclampsia (PE), hypertension and proteinuria developing after 20 weeks of gestation, is the cause of maternal and fetal deaths. The only definitive treatment currently available to save the mother and/or the baby is induced delivery. Anti-hypertensives acceptable for use during pregnancy help control maternal blood pressure in PE, but they do not prevent pre-term delivery nor correct the fetal growth restriction associated with PE. We have demonstrated that nicotinamide reduces the hypertension and proteinuria in mice having a pre-eclampsia-like condition, delays miscarriages and alleviates the fetal growth restriction. Nicotinamide is the first substance that benefits both mother and offspring by targeting a pathway specifically dysfunctional in PE. It merits evaluation for preventing or treating PE in humans.
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[Journal Article] eNOS deficiency acts through endothelin to aggravate sFlt-1-induced preeclampsia-like phenotype2012
Author(s)
Li F, Hagaman JR, Kim H-S, Maeda N, Jennette JC, Faber JE, Karumanchi, SA, Smithies O, Takahashi, N et al.
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Journal Title
J Am Soc Nephrol
Volume: 23
Pages: 652-660
DOI
Peer Reviewed
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