2013 Fiscal Year Final Research Report
Epigenetic mechanisms underlying renal derangement in hypertension and diabetes
| Project/Area Number |
24659410
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Kidney internal medicine
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| Research Institution | The University of Tokyo |
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Principal Investigator |
FUJITA Toshiro 東京大学, 先端科学技術研究センター, 特任研究員、名誉教授 (10114125)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 糖尿病性腎症 / 高血圧 / 食塩 / エピジェネティクス |
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| Research Abstract |
Diabetes is often complicated with hypertension, but the underlying mechanisms have not been clarified. We investigated whether epigenetic derangement in the kidney underlies hypertension in diabetic model animals.
Because kidney is composed with multiple cell types, we sorted proximal tubule cells and investigated the differential DNA methylation status. In normal mice, DNA methylation of multiple genes including those involved in blood pressure regulation was selectively demethylated in proximal tubules. In db/db mice, diabetic mice with salt sensitive hypertension, aberrant DNA methylation and mRNA changes were detected in some of the genes related to blood pressure regulation. These results suggest that epigenetic abnormalities may underlie hypertension in diabetes.
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[Journal Article] A novel link between Slc22a18 and fat accumulation revealed by a mutation in the spontaneously hypertensive rat2013
Author(s)
Y amamoto, T., Izumi-Yamamoto, K., Iizuka, Y., Shirota, M., Nagase, M., Fujita T., and Gotoda, T.
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Journal Title
Biochem Biophys Res Commun
Volume: 440
Pages: 512-526
DOI
Peer Reviewed
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[Journal Article] 2013. Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency2013
Author(s)
Jimbo, R., Kawakami-Mori, F., Mu, S., Hirohama, D., Majtan, B., Shimizu, Y., Yatomi, Y., Fukumoto, S., Fujita T., and Shimosawa, T.
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Journal Title
DOI
Peer Reviewed
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[Journal Article] 2013. A useful method of identifying of miRNAs which can down-regulate Zeb-22013
Author(s)
Oba, S., Mizutani, T., Suzuki, E., Nishimatsu, H., Takahashi, M., Ogawa, Y., Kimura, K., Hirata, Y., and Fujita T.
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Journal Title
BMC Res Notes
Volume: 6
Pages: 470
DOI
Peer Reviewed
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[Journal Article] 2013. Oxidative stress augments pulmonary hypertension in chronically hypoxic mice overexpressing the oxidized LDL receptor2013
Author(s)
Ogura, S., Shimosawa, T., Mu, S., Sonobe, T., Kawakami-Mori, F., Wang, H., Uetake, Y., Yoshida, K., Yatomi, Y., Shirai, M., and Fujita T.
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Journal Title
Am J Physiol Heart Circ Physiol
Volume: 305
Pages: H155-162
DOI
Peer Reviewed
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