Role of secreted FSP1 in the progression of diabetic nephropathy, especially in podocyte-mesangial crosstalk.

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659415
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Kidney internal medicine
• Research Institution: University of Fukui
• Principal Investigator: IWANO MASAYUKI 福井大学, 医学部, 教授 (20275324)
• Co-Investigator(Kenkyū-buntansha): KASUNO Kenji 福井大学, 医学部, 准教授 (60455243) ; TAKAHASHI Naoki 福井大学, 医学部附属病院, 助教 (30377460) ; MIKAMI Daisuke 福井大学, 医学部附属病院, 助教 (90464586)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: ＦＳＰ１ / ＲＡＧＥ / ポドサイト / メサンギウム細胞

Research Abstract

FSP1-positive podocytes were observed in active glomerular damage. In this study, we investigated whether secreted FSP1 from podocytes has some biological effects on cultured mesangial cells through secreted FSP1 receptor, RAGE. We newly found that recombinant FSP1 induced five renoprotective factors and suppressed one factor associated with glomerular injury in cultured mesangial cells and these induction and suppression were not mediated through RAGE. These results suggest that secreted FSP1 has renoprotective effects and play a role in podocyte-mesangial crosstalk.

Research Products

• [Journal Article] Downregulation of renal type IIa sodium-dependent phosphate cotransporter during lipopolysaccharide-induced acute inflammation (2014)
  • Author(s): Ikeda S, Yamamoto H, Masuda M, Takei Y, Nakahashi O, Kozai M, Tanaka S, Nakao M, Taketani Y, Segawa H, Iwano M, Miyamoto K, Takeda E.
  • Journal Title: Am J Physiol Renal Physiol Volume: 306(7) Pages: F744-50
  • DOI: 10.1152/ajprenal.00474.2013
  • Peer Reviewed
• [Journal Article] Reduced renalα-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism (2014)
  • Author(s): Sakan H, Nakatani K, Asai O, Imura A, Tanaka T, Yoshimoto S, Iwamoto N, Kurumatani N, Iwano M, Nabeshima Y, Konishi N, Saito Y.
  • Journal Title: PLoS One Volume: 9(1) Pages: e86301
  • DOI: 10.1371/journal.pone.0086301
  • Peer Reviewed
• [Journal Article] Telmisartan activates endogenous peroxisome proliferator- activated receptor-δand may have anti-fibrotic effects in human mesangial cells (2014)
  • Author(s): Mikami D, Kimura H, Kamiyama K, Torii K, Kasuno K, Takahashi N, Yoshida H, Iwano M.
  • Journal Title: Hypertens Res Volume: 37(5) Pages: 422-31
  • DOI: 10.1038/hr.2013.157
  • Peer Reviewed
• [Journal Article] Suppressed soluble Fms-like tyrosine kinase-1 production aggravates atherosclerosis in chronic kidney disease (2014)
  • Author(s): Matsui M, Takeda Y, Uemura S, Matsumoto T, Seno A, Onoue K, Tsushima H, Morimoto K, Soeda T, Okayama S, Somekawa S, Samejima K, Kawata H, Kawakami R, Nakatani K, Iwano M, Saito Y.
  • Journal Title: Kidney Int Volume: 85(2) Pages: 393-403
  • DOI: 10.1038/ki.2013.339
  • Peer Reviewed
• [Journal Article] Significance of renal biopsy in patients with presumed diabetic nephropathy (2013)
  • Author(s): Harada K, Akai Y, Sumida K, Yoshikawa M, Takahashi H, Yamaguchi Y, Kubo A, Iwano M, Saito Y.
  • Journal Title: J Diabetes Invest Volume: 4 Pages: 88-93
  • DOI: 10.1111/j.2040-1124.2012.00233.x
  • Peer Reviewed
• [Journal Article] Rapid detection of the Mycobacterium tuberculosis complex by use of quenching probe PCR (geneCube) (2012)
  • Author(s): Hida Y, Hisada K, Shimada A, Yamashita M, Kimura H, Yoshida H, Iwasaki H, Iwano M.
  • Journal Title: J Clin Microbiol Volume: 50(11) Pages: 3604-8
  • DOI: 10.1128/JCM.01654-12
  • Peer Reviewed
• [Presentation] 新規TLR4阻害因子・分泌型FSP1を介したポドサイトーメサンギウム細胞連関 (2014)
  • Author(s): 横井靖二、岩野正之, 他
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-07-06
• [Presentation] 結節病変を有した糖尿病性腎症例における腎予後と臨床および病理組織学的指標との関連性 (2012)
  • Author(s): 森本勝彦、岩野正之, 他
  • Organizer: 第55回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2012-06-03