2013 Fiscal Year Final Research Report
Induction of regulatory microglia and its therapeutic development
| Project/Area Number |
24659430
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Nagoya University |
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Principal Investigator |
MIZUNO Tetsuya 名古屋大学, 環境医学研究所, 准教授 (70335008)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ミクログリア / IL-34 / TGF / 神経保護作用 |
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| Research Abstract |
Microglia have a biphasic neurotoxic or neuroprotective role in the pathogenesis of various neurodegenerative diseases. In this study, we examined the method for microglial differentiation into neuroprotective cells. We clarified that treatment of IL-34 and TGF for 7 days induces neuroprotective property in microglia, which exert neuroprotection against amyloid beta toxicity.
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