2014 Fiscal Year Final Research Report
Systematic survey for biologically active peptides in pheochromocytoma tissue.
| Project/Area Number |
24659452
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUWASAKO Kenji 宮崎大学, フロンティア科学実験総合センター, 准教授 (20381098)
NAGATA Sayaka 宮崎大学, 医学部, 特任助教 (00452920)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 褐色細胞腫 / 受容体 / 新規生理活性ペプチド / cAMP / アミド化 / 血管作動性物質 / Big angiotensin-25 / ラジオイムノアッセイ |
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| Outline of Final Research Achievements |
We have performed the systematic survey for biologically active peptides in human pheochromocytoma tissue, using assay systems which we had originally established. We have purified and determined more than 50 peptides from human pheochromocytoma tissue. We discovered Big angiotensin-25 from human urine as an endogenous peptide. Further we have developed the assay system for Big angiotensin-25.
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| Free Research Field |
医師薬学
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