2013 Fiscal Year Final Research Report
Application of the novel intestinal hormone, IBCAP targeted pancreas beta-cell regeneration therapy.
| Project/Area Number |
24659453
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Endocrinology
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAZAKI Yasushi 埼玉医科大学, 医学部, 教授 (80280733)
TOYOSHIMA Hideo 埼玉医科大学, 医学部, 客員准教授 (20197966)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 糖尿病 |
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| Research Abstract |
IBCAP (intestine derived beta-cell augmenting promoter) is another intestine-specific secretory protein with incretin-like activity, identified in our laboratory. IBCAP have pancreatic beta-cell proliferation activity in vitro. And, insulin positive cells were demonstrated in the liver of STZ treated type 1 diabetes model mice infected with IBCAP expressing adenovirus. Our results indicate that IBCAP could have an activity to induce not only proliferation but also differentiation of beta-cells. IBCAP may be used as a potent inducer for pancreatic beta-cell regeneration.
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[Journal Article] Expression of IBCAP (intestine-derived beta-cell augmenting promoter), an intestine specific secretory factor, induces insulin positive cells in the liver2012
Author(s)
Yokoo T, Watanabe K, Iida KT, Suzuki H, Shimano H, Kawakami M, Yamada N, Okazaki Y, Toyoshima H.
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Journal Title
Diabetologia
Volume: 55(Suppl1)
Pages: S182
DOI
Peer Reviewed
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[Presentation] Expression of IBCAP (intestine-derived beta-cell augmenting promoter), an intestine specific secretory factor, induces insulin positive cells in the liver2012
Author(s)
Yokoo T, Watanabe K, Iida KT, Suzuki H, Shimano H, Kawakami M, Yamada N, Okazaki Y, Toyoshima H.
Organizer
48th EASD Annual Meeting
Place of Presentation
Berlin, Germany
Year and Date
2012-10-02
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