2014 Fiscal Year Final Research Report
Gene mutations in hematopoietic stem cells of chronic lymphocytic leukemia
| Project/Area Number |
24659462
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Hematology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | 慢性リンパ性白血病 / 造血幹細胞 / 白血化機構 |
|---|
| Outline of Final Research Achievements |
Chronic lymphocytic leukemia (CLL) is a mature B cell malignancy, which has been considered to originate from mature B cells. We reported that even in CLL, very primitive hematopoietic stem cells (HSCs) should be involved in the pathogenesis of CLL. In this study, we tried to identify the somatic mutations acquired in primary CLL cells, and test whether such somatic mutations could be detected within HSCs of the CLL patients. We found that some of the identical somatic mutations acquired in CLL cells could be traced back to CD34+ human hematopoietic stem progenitor cells (HSPCs) and myeloid cells of the CLL patients. These results collectively suggest that early mutations associated with CLL pathogenesis should be acquired and accumulated within the self-renewing HSCs in human, and these abnormal pre-leukemic HSCs play a significant role in the multi-step leukemia progression processes of CLL.
|
| Free Research Field |
血液内科学
|
