Role for MDSC in the pathogenesis of autoimmune diseases and its application for therapy

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659473
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Kobe University
• Principal Investigator: MORINOBU Akio 神戸大学, 医学(系)研究科(研究院), 准教授 (10294216)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 関節リウマチ / 抑制性単球 / JAK阻害剤

Research Abstract

We have examined the role for MDSC (myeloid derived suppressor cells) in SKG arthritis model mouse. MDSC number was increased in arthritic mice and injection of MDSC reduced arthritis, indicating that MDSC is induced in arthritis and inhibits arthritis. Furthermore, we found that a JAK inhibitor up-regukates MDSCs in arthritis model mouse in vivo, and depletion of MDSC by anti-Gr-1 antibody accelerated arthritis, indicating that JAK inhibitor ameliorates arthritis in part by inducing MDSC. MDSC is deeply involved in arthritis and could be a thrapeutic target.

Research Products

• [Journal Article] GC/MS-based metabolomics detects metabolic alterations in serum from SLE patients (2014)
  • Author(s): Saegusa J, Irino Y, Yoshida M, Tanaka S, Kogata Y, Kageyama G, Tsuji G, Takenawa T, Kawano S, Kumagai S, Morinobu A.
  • Journal Title: Clin Exp Rheumatol Volume: 32(1) Pages: 148
  • Peer Reviewed
• [Journal Article] CD45RA-Foxp3high activated/effector regulatory T cells in the CCR7+CD45RA-CD27+CD28+central memory subset are decreased in peripheral blood from patients with rheumatoid arthritis (2013)
  • Author(s): Matsuki F, Saegusa J, Miyamoto Y, Misaki K, Kumagai S, Morinobu A.
  • Journal Title: Biochem Biophys Res Commun Volume: 438(4)(pii : S0006-291X(13)00938-8) Pages: 778-83
  • Peer Reviewed
• [Presentation] TofacitinibはMyeloid-derived suppressor cellを誘導し、SKGマウス関節炎を抑制する (2014)
  • Author(s): 西村啓佑、三枝淳、明石健吾、西田美和、高橋宗史、古形芳則、蔭山豪一、森信暁雄
  • Organizer: 日本リウマチ学会学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-24
• [Presentation] Tofacitinib fascilitates expansion of myeloid derived suppressor cells and ameliorates arthritis in SKG mice (2013)
  • Author(s): Nishimura K, Saegusa J, Akashi K, Morinobu A.
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2013-12-12
• [Presentation] CD45RA-FoxP3 high activated/effector T regulatory cells in the CCR7+CD45RA-CD27+CD28+ central memory subset are decreased in peripheral blood from patients with RA (2013)
  • Author(s): Saegusa J, Kumagai S, Morinobu A.
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張
  • Year and Date: 2013-12-12
• [Presentation] TofacitinibはMyeloid-derived suppressor cellを誘導し、マウス関節炎を抑制する (2013)
  • Author(s): 西村啓佑、三枝淳,松木郁親,田中姿乃,明石健吾,森信暁雄
  • Organizer: 日本臨床免疫学会
  • Place of Presentation: 下関
  • Year and Date: 2013-11-27