2012 Fiscal Year Final Research Report
Investigation into the molecular mechanisms for the occurrence of leukemia using iPS cells derived from congenital bone marrow failure syndrome and establishment of the methods to prevent its occurrence
| Project/Area Number |
24659489
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
EBIHARA Yasuhiro 東京大学, 医科学研究所, 助教 (40302608)
MOCHIZUKI Shinji 東京大学, 医科学研究所, 特任助教 (90349473)
OHTSU Makoto 東京大学, 医科学研究所, 特任准教授 (30361330)
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| Project Period (FY) |
2012
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| Keywords | 小児血液学 / iPS細胞 |
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| Research Abstract |
We established iPS cells from somatic cells of a patient with severe congenital neutropenia (SCN), one of congenital bone marrow failure syndrome (SCN-iPS cells). Myeloid cells derived from SCN-iPS cells revealed the maturation arrest at a promyelocyte stage, reflecting the symptom of SCN patients. The gene expression analysis-catenin pathway-related genes, and exogenous Wnt3a induced the improvement in the maturation arrest of SCN-iPS cell-derived myeloid cells. These results indicated the involvement of -catenin pathway in the maturation arrest of myeloid cells in SCN patients and the possibility of novel therapies by activating the pathway. In addition, SCN-iPS cells were expected to be useful for the investigation into the mechanisms causing the occurrence of leukemia and the establishment of the methods to prevent it in SCN.
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