2013 Fiscal Year Final Research Report
Cell therapy against intractable EB virus infection using immunological tolerance
| Project/Area Number |
24659493
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Nagoya University |
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Principal Investigator |
KIMURA Hiroshi 名古屋大学, 医学(系)研究科(研究院), 教授 (30303621)
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| Co-Investigator(Kenkyū-buntansha) |
GOSHIMA Fumi 名古屋大学, 大学院医学系研究科, 助教 (70201499)
KAMAKURA Maki 名古屋大学, 大学院医学系研究科, COE特任助教 (80437003)
ITO Yoshinori 名古屋大学, 医学部附属病院, 講師 (20373491)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 細胞療法 / 慢性活動性EBV感染症 / 母子間マイクロキメリズム / 免疫寛容 |
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| Research Abstract |
Severe Epstein-Barr virus (EBV) infections, such as chronic active EBV infection and EBV-associated hemophagocytic lymphohistiocytosis, are refractory to therapies and intractable diseases. Recently, fetal-maternal lymphohematopoietic microchimerism can be detected in blood from healthy individuals, and immunological tolerance exists between mothers and children. In this study, in order to develop novel therapies for severe EBV infections, fundamental studies including the proof of fetomaternal microchimerism have been performed for establishing cell therapy.
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[Journal Article] Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder : a case report2013
Author(s)
Kato S, Miyata T, Takata K, Shimada S, Ito Y, Tomita A, Elsayed AA, Takahashi E, Asano N, Kinoshita T, Kimura H, Nakamura S.
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Journal Title
Hum Pathol
Volume: 44
Pages: 2849-52
DOI
Peer Reviewed
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[Journal Article] Epstein-Barr virus (EBV)-associated T/NK lymphoproliferative diseases in non-immunocompromised hosts : prospective analysis of 108 cases2012
Author(s)
Kimura H, Ito Y, Kawabe S, Gotoh K, Takahashi Y, Kojima S, Naoe T, Esaki S, Kikuta A, Sawada A, Kawa K, Ohshima K, Nakamura S.
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Journal Title
Blood
Volume: 119
Pages: 673-86
DOI
Peer Reviewed
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[Journal Article] EBV-associated T and NK cell lymphoproliferative disorders : Consensus report of the 4th Asian Hematopathology Workshop2012
Author(s)
Ko Y-H, Kim H-J, Oh Y-H, Park G, Lee S-S, Huh J, Kim C-W, Kim I, Ng S-B, Tan S-Y, Chuang S-S, Nakamura N, Yoshino T, Nakamura S, Kimura H, Ohshima K.
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Journal Title
J Hematopathol
Volume: 5
Pages: 319-324
URL
Peer Reviewed
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