2014 Fiscal Year Final Research Report
Model for generation of leukemic stem cells: spatio-temporal properties in pathogenesis
| Project/Area Number |
24659494
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | Mie University |
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Principal Investigator |
NOSAKA Tetsuya 三重大学, 医学(系)研究科(研究院), 教授 (30218309)
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| Co-Investigator(Renkei-kenkyūsha) |
ONO Ryoichi 三重大学, 大学院医学系研究科, 講師 (40422414)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 白血病 / 白血病幹細胞 / ＭＬＬ / ＭＬＬ－ＥＮＬ |
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| Outline of Final Research Achievements |
The goal of this study is to clarify the molecular mechanism for generation of leukemic stem cells by using the inducible MLL-ENL transgenic mice which we made.
The efficiency of immortalization of fetal liver cells was lower than that of adult bone marrow cells when MLL-ENL was inducibly expressed. In addition, we found that Tet1 which is known to be involved in self renewal of embryonic stem cells, negatively regulates the leukemogenesis in this model system.
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| Free Research Field |
血液学
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