Post-ischemic reperfusion injury inhibiting effect of the new compound dichloroacetylcarnitine

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659501
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: ITOI TOSHIYUKI 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (10264780)
• Co-Investigator(Kenkyū-buntansha): TOIYAMA Kentaro 京都府立医科大学, 大学院医学研究科, 助教 (00433285) ; OKA Tatsujiro 京都府立医科大学, 大学院医学研究科, 研究員 (80433283)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 再灌流障害 / ジクロル酢酸 / カルニチン / 新化合物 / 心筋

Outline of Final Research Achievements

Our aim of this study was to synthesize new low-molecular compound which has pharmacological effects of both dichloroacetate and acetyl-carnitine and to analyze its effect of organ protection.
We synthesized basic molecular platform in 2012 and succeeded to produce new compound A which was induced biological equivalent substituent during 2013-2014. The functional recovery rate of reperfused rat heart under isolated heart perfusion system was significantly high of 73±38% in compound A group in comparison with the control group of 14±6%. The structure of the new compound was concealed because this was under pending patent application.

Free Research Field

小児循環器