2012 Fiscal Year Final Research Report
Pathomechanism for increased ectodomain shedding of collagen XVIIby targeting coiled-coils
| Project/Area Number |
24659514
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dermatology
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| Research Institution | Hokkaido University |
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Principal Investigator |
NISHIE Wataru 北海道大学, 北海道大学病院, 講師 (20443955)
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| Project Period (FY) |
2012
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| Keywords | 皮膚生理学 |
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| Research Abstract |
Collagen XVII (COL17) is the major autoantigen for bullous pemphigoid. Juxtamembranous NC16A domain of COL17 contains major epitopes, in which potential coiled-coil exits. The aim of this study is to address the pathomechanism of the coiled-coils. The experiments disclosed that coiled-coils are essential motives for COL17 to form triple-helical structure; in addition the motived can be targeted by proteases when miss-folded COL17 are produced. Thus, the domain has a novel vital role for quality checking of folded COL17.
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