New method of cognitive behavior therapy for adolescent depression considering the gender difference in mind and brain, and social development

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659538
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Psychiatric science
• Research Institution: Chiba University
• Principal Investigator: SHIMIZU Eiji 千葉大学, 医学(系)研究科(研究院), 教授 (00292699)
• Co-Investigator(Renkei-kenkyūsha): MATSUZAWA Daisuke 千葉大学, 大学院医学研究院, 講師 (10447302)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 認知行動療法 / 思春期うつ病 / 性差

Research Abstract

After developed disorder-specific cognitive behavior therapy (CBT), we have gotten an idea the pathologically specific CBT program for depression would be more effective. In the program, we considered that the patient's age and gender would be important factors. In this study, we used animal model to examine the gender difference in fear response and its extinction, and the effect of social interaction for the therapy results. From the clinical point of view, by surveying high school students, female students showed more depressive mood and social anxiety than male students. We developed a new CBT protocol for the adolescent female depression.

Research Products

• [Journal Article] Social Skills Training Encourages a Patient with Social Anxiety Disorder to Undertake Challenging Behavioral Experiments (2014)
  • Author(s): Yoshinaga N, Shimizu E
  • Journal Title: British Journal of Medicine and Medical Research Volume: 4(3) Pages: 905-913
  • DOI: 10.9734/BJMMR/2014/5612
  • Peer Reviewed
• [Journal Article] Cognitive Behaviour Therapy Using the Clark & Wells Model : A Case Study of a Japanese Social Anxiety Disorder Patient (2013)
  • Author(s): Yoshinaga N, Kobori O, Iyo M, Shimizu E
  • Journal Title: the Cognitive Behaviour Therapist Volume: 6(e3)
  • DOI: 10.1017/S1754470X13000081
  • Peer Reviewed
• [Journal Article] A Transient Fear Reduction by Pair-Exposure with a Non-Fearful Partner during Fear Extinction Independent from Corticosterone Level in Mice (2013)
  • Author(s): Tomizawa,H., Matsuzawa, D., Matsuda,S., Ishii D., Sutoh C., Shimizu E
  • Journal Title: Journal of Behavioral Brain Science Volume: 3 Pages: 415-421
  • DOI: 10.4236/jbbs.2013.35043
  • Peer Reviewed
• [Journal Article] Perinatal exposure to bisphenol A enhances contextual fear memory and affects the serotoninergic system in juvenile female mice (2013)
  • Author(s): Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Sajiki J, Shimizu E
  • Journal Title: Horm Behav Volume: 63(5) Pages: 709-16
  • DOI: 10.1016/j.yhbeh.2013.03.016
  • Peer Reviewed
• [Journal Article] Effects of perinatal exposure to low dose of bisphenol A on anxiety like behavior and dopamine metabolites in brain (2012)
  • Author(s): Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Sutoh C, Nakazawa K, Amano K, Sajiki J, Shimizu E
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 39(2) Pages: 273-9
  • DOI: 10.1016/j.pnpbp.2012.06.016
  • Peer Reviewed
• [Journal Article] No erasure effect of retrieval-extinction trial on fear memory in the hippocampus-independent and dependent paradigms (2012)
  • Author(s): Ishii D, Matsuzawa D, Matsuda S, Tomizawa H, Sutoh C, Shimizu E
  • Journal Title: Neurosci Lett Volume: 523(1) Pages: 76-81
  • DOI: 10.1016/j.neulet.2012.06.048
  • Peer Reviewed
• [Presentation] Sex Differences in Effect of Consecutive Fear Ex on Spontaneous Recovery (2013)
  • Author(s): Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Sutoh C, Shimizu E
  • Organizer: Society for Neuroscience 43rd Annual Meeting
  • Place of Presentation: San Diego, USA
  • Year and Date: 2013-11-09
• [Presentation] Individual Cognitive Behavior Therapy for Japanese Patients with Social Anxiety Disorder : Preliminary Outcomes and Their Predictors (2013)
  • Author(s): Yoshinaga N, Matsuki S, Kobori O, Shimizu E
  • Organizer: 43rd Annual Congress of The European Association for Behavioural and Cognitive Therapies
  • Place of Presentation: Marrakech, Morocco
  • Year and Date: 2013-09-27
• [Presentation] A Feasibility Study of Individual Cognitive Behavior Therapy for Social Anxiety Disorder in Japanese (2013)
  • Author(s): Yoshinaga N, Ohshima F, Matsuki S, Tanaka M, Kobayashi T, Ibuki H, Asano K, Kobori O, Shiraishi T, Ito E, Nakazato M, Nakagawa A, Iyo M, Shimizu E
  • Organizer: Clinical Settings 7th World Congress of Cognitive and Behavioural
  • Place of Presentation: Therapies Lima, Peru
  • Year and Date: 2013-07-24
• [Presentation] Effects of adult ovariectomy on fear extinction and recovery (2013)
  • Author(s): Matsuda S, Matsuzawa D, Ishii D, Tomizawa H, Shimizu E
  • Organizer: 第36回日本神経科学大会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2013-06-22
• [Presentation] Effect of brain development during adolescence on recovery of fear Society for Neuroscience (2012)
  • Author(s): Ishii D, Matsuzawa D, Matsuda S, Tomizawa H, Sutoh C, Shimizu E
  • Organizer: 42th Annual Meeting
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2012-10-15
• [Presentation] No erasure effect of retrieval-extinction trial on fear memory (2012)
  • Author(s): Ishii D, Matsuzawa D, Matsuda S, Tomizawa H, Sutoh C, Shimizu E
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-09-21
• [Presentation] Effects of non-fearful partner on fear extinction memory and corticosterone level (2012)
  • Author(s): Tomizawa H, Matsuzawa D, Matsuda S, Ishii D, Sutoh C, Shimizu E
  • Organizer: 第35回日本神経科学大会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2012-09-21
• [Remarks] 千葉大学大学院医学研究院認知行動生理学 ホームページ(業績欄)
  • URL: http://www.m.chiba-u.ac.jp/class/phys1/result/result.html