Development of physiological vascular function measurements

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659550
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: YOSHINAGA Keiichiro 北海道大学, 医学(系)研究科(研究院), 客員研究員 (30435961)
• Co-Investigator(Kenkyū-buntansha): KATOH Chietugu 北海道大学, 大学院保健科学研究院, 教授 (10292012) ; YAMADA Satoshi 北海道大学, 北海道大学病院, 助教 (80374320) ; NISHIDA Mutsumi 北海道大学, 北海道大学病院, 副臨床検査技師長 (90404722) ; NISHIO Saori 北海道大学, 北海道大学病院, 助教 (90463736)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: オシロメトリック法 / 動脈硬化 / 血管内皮機能 / 血管径 / 超音波検査

Outline of Final Research Achievements

Background: We aimed to investigate whether VE and eA response to nitroglycerin (NTG) reflected endothelial and endothelial independent dysfunction related to chronic kidney disease (CKD). Methods: 13 CKD and 15 controls were studied. Rest VE and eA response to NTG were measured by novel automated oscillometric detector. eA was estimated using pressure-volume curves and VE was defined as follows [VE=ΔPressure/ (100XΔarea/Area) mmHg/%]. Ultrasound measurements of flow mediated vasodilatation (FMD) and NTG were used as standard.Results: Rest eA and VE showed good reproducibility (eA: ICC = 0.88, VE: ICC = 0 .78).　Rest Ve was negatively correlated with %FMD(r=-0.43, P=0.02). Conclusions: This new automated vascular function measurement using oscillometric measurement reliably detected endothelial dysfunction related to CKD and has potential to detect endothelial independent vasodilator response.

Free Research Field

放射線医学