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2013 Fiscal Year Final Research Report

Evaluation of F-18 labeled fluoroacetate as an imaging probe for glial function

Research Project

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Project/Area Number 24659560
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionUniversity of Fukui

Principal Investigator

KIYONO Yasushi  福井大学, 高エネルギー医学研究センター, 教授 (50305603)

Co-Investigator(Kenkyū-buntansha) MORI Tetsuya  福井大学, 高エネルギー医学研究センター, 助教 (40397287)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywords放射線 / 放射性医薬遺品 / グリア / PET
Research Abstract

It is expected to develop imaging probes for glial function. Therefore, in this study, F-18 labeled acetic acid derivative, F-18 labeled fluoroacetate was evaluated as an imaging probe for glial function.
In in vitro cell uptake experiments, it was observed that F-18 labeled fluoroacetate was uptaken into astocytes. On the other hand, F-18 labeled fluoroacetate was not uptaken into microglia. In PET imaging experiments, the accumulation of F-18 labeled fluoroacetate in the brain was peaked at 3 min post injection, and then the radioactivity was maintained in the same level.
These results suggest that F-18 labeled fluoroacetae has the possibility to image the glial function and to measure the energetic metabolism in the glia.

  • Research Products

    (4 results)

All 2014 2013

All Presentation (4 results)

  • [Presentation] Development of a flexible synthesis module system for F-18 labeled PET tracer2014

    • Author(s)
      T.Mori, T.Takaki, Y.Fujibayashi, T.Asai, H.Okazawa, Y.Kiyono
    • Organizer
      International Workshop on Molecular Functional Imaging for Brain and Gynecologic Oncology
    • Place of Presentation
      Fukui, Japan
    • Year and Date
      20140303-04
  • [Presentation] Fully automated production of [^<18>F]fluoroacetate on a compact FDG synthesizer2014

    • Author(s)
      T.Mori, R.Arai, D.Blampain, T.Kosuga, T.Asai, Y.Fujibayashi, H.Okazawa, Y.Kiyono
    • Organizer
      International Workshop on Molecular Functional Imaging for Brain and Gynecologic Oncology
    • Place of Presentation
      Fukui, Japan
    • Year and Date
      20140303-04
  • [Presentation] 汎用型PET薬剤自動合成システムの開発と実用性試験2013

    • Author(s)
      森哲也,高木健志,藤林靖久,岡沢秀彦,清野泰
    • Organizer
      第53回日本核医学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      20131108-10
  • [Presentation] Fully automated production of [^<18>F]fluoroacetate on IBA Synthera platform2013

    • Author(s)
      T.Mori, R.Arai, D.Blampain, C.Gameiro-Paris, T.Kosuga, T.Asai, Y.Fujibayashi, H.Okazawa, Y.Kiyono
    • Organizer
      20th International Symposium on Radiopharmaceutical Sciences
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      20130512-17

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Published: 2015-06-25  

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