Basic research for the optimization of stereotactic radiotherapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659563
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: ITASAKA SATOSHI 京都大学, 医学(系)研究科(研究院), 非常勤講師 (90378654)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 放射線治療 / 腫瘍内低酸素 / 定位放射線治療

Outline of Final Research Achievements

In this study, changes of intra-tumoral hypoxia, HIF-1 activity, and vasculature after a large dose single irradiation were evaluated, sequentially. Effects of large dose irradiation on tumors and normal tissues were evaluated at the same time. It was also tried to find factors that enhance the therapeutic effects. Human lung cancer cell line H441 transfected with HIF-1 responsible luciferase gene were implanted into the nude mice, subcutaneously. The temporal changes of intra-tumoral hypoxia were observed as HIF-1 activity change by optical imaging. Optimal timing of the second irradiation was evaluated using the HIF-1 imaging to maximize the therapeutic effects of irradiation. We could not identify new therapeutic targets that can enhance the effect of radiation therapy.

Free Research Field

放射線治療