Effects of Internal Radiation by Radioactive Cesium on glucose and insulin metabolism

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659570
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Fukushima Medical University
• Principal Investigator: SATOH Hiroaki 福島県立医科大学, 医学部, 准教授 (20323595)
• Co-Investigator(Renkei-kenkyūsha): YAMAZAKI Satoru 福島医科大学, 医学部, 研究院 (50622792)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 放射性セシウム内部被爆 / インスリン抵抗性 / アディポネクチン

Outline of Final Research Achievements

In current study, we investigated the effect of internal radioactive cesium exposure on insulin sensitivity in male Wistar rats, whereby insulin sensitivity was measured directly using the hyperinsulinemic-euglycemic glucose clamp studies. Male Wistar rats were fed NCD, or HFD containing with either radioactive cesium or not, for 5 weeks. In the NCD fed rats, during the clamp studies, GIR, cHGO, and IS-GDR were no significant changes between two groups. On the other hand, in the HFD fed rats, the GIR and IS-GDR were significantly decreased in internal radioactive cesium exposure group compared to in the HFD control group. Furthermore, in the clamp studies, the adenovirus mediated adiponectin overexpression rats exhibited increased GIR and IS-GDR compared to the HFD fed internal radioactive cesium exposure rats.
In conclusion, the internal radiation by radioactive cesium exacerbates the HFD induced insulin resistance in male Wister rats, but adiponectin improves these affects.

Free Research Field

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