2013 Fiscal Year Final Research Report
Study on new tumor imaging by cell labelling method
| Project/Area Number |
24659571
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
NAKAGAMI Yoshihiro 独立行政法人国立がん研究センター, 東病院, 医長 (80347301)
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| Co-Investigator(Kenkyū-buntansha) |
HARA Takamitsu 福島県立医科大学, 医学部, 准教授 (70464542)
INOUE Tomio 横浜市立大学, 大学院医学研究科, 教授 (80134295)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 細胞標識 / cell-in-cell活性 |
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| Research Abstract |
In late years the report about special T cell "HOZOT cell" with the property that a cancer cell specifically attracted was accomplished. Using HOZOT cell, We develop a nuclear medicine diagnostic method with the specificity for a cancer and are intended to aim at the application to the nuclear medicine cure for cancer more in this study. We succeeded in labelling HOZOT cell with indium-111, and I administered this intravenously to the mice with human breast cancer, and we imaged them with SPECT-CT device for animals, but unfortunately the accumulation of the HOZOT cell only was diffusely seen in the whole both lungs, and had little meaningful accumulation to the cancer organization. We could label HOZOT cell by nuclides except indium-111 and want to enable the imaging of a cancer with them in future.
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