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2013 Fiscal Year Final Research Report

Establishment of a novel method for brain activity dependent neuroimaging

Research Project

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Project/Area Number 24659574
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

CUI Yilong  独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (60312229)

Co-Investigator(Kenkyū-buntansha) WADA Yasuhiro  独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, 副チームリーダー (40382197)
Project Period (FY) 2012-04-01 – 2014-03-31
KeywordsPET / 脳機能画像 / 神経活動
Research Abstract

In order to establish a novel method for a neuronal activity-dependent neuroimaging analysis, a non-metal imaging device was fabricated to record the neurophysiological changes and PET scans simultaneously. The numerical model-based attenuation correction was implemented to correct for the lower counts induced by the device. The radioactivity in the blood quickly achieved a steady state after the intravenous injection of FDG combining bolus injection and continuous infusion, whereas it was continuously increased in the brain. Moreover, the electrical stimulation-related functional neuroimages were reconstructed by a trigger driven gating method in which every 5-sec PET list mode data were sorted into a gate sinogram according to a time-stamp driven by a trigger signal which was synchronized with the electrical stimulation.

  • Research Products

    (13 results)

All 2013 2012

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (6 results)

  • [Journal Article] Apomorphine-induced modulation of neural activities in the ventrolateral striatum of rats2013

    • Author(s)
      Fujita S., Kato R., Cui, Y.L., Terakado M., Suga K., Koshikawa N., Kobayashi M
    • Journal Title

      Synapse

      Volume: 67 Pages: 363-373

    • DOI

      10.1002/syn.21644

    • Peer Reviewed
  • [Journal Article] Functional anatomy of gustation in the alert rat revealed by positron emission tomography2013

    • Author(s)
      Kobayashi, M., Cui, Y.L.., Sako, T., Sasabe, T., Mizoguchi, N., Wada, Y., Kataoka, Y., Koshikawa, N
    • Journal Title

      J Neurosci Res

      Volume: 91 Pages: 1363-1370

    • DOI

      10.1002/jnr.23252

    • Peer Reviewed
  • [Journal Article] Synthesis of an 11C-labeled antiprion GN8 derivative and evaluation of its brain uptake by positron emission tomography2013

    • Author(s)
      Kimura, T., Sako, T., Siqin, Hosokawa-Muto, J., Cui, Y.L., Wada, Y., Kataoka, Y., Doi, H., Sakaguchi, S., Suzuki, M., Watanabe, Y., Kuwata, K
    • Journal Title

      ChemMedChem

      Volume: 8 Pages: 1035-1039

    • DOI

      10.1002/cmdc.201300167

    • Peer Reviewed
  • [Journal Article] Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion using Newly Developed Positron Emission Tomography (PET) Tracer, [11C]Dehydropravastatin, in Rats2013

    • Author(s)
      Shingaki, T., Takashima, T., Ijuin, R., Zhang, X., Onoue, T., Katayama, Y., Okauchi, T., Hayashinaka, E., Cui, Y.L., Wada, Y., Suzuki, M., Maeda, K., Kusuhara, H., Sugiyama, Y. and Watanabe, Y
    • Journal Title

      J Pharmacol Exp Ther

      Volume: 347(1) Pages: 193-202

    • DOI

      10.1124/jpet.113.206425

    • Peer Reviewed
  • [Journal Article] Positron emission tomography study on pancreatic somatostatin receptors in normal and diabetic rats with Ga-DOTA-octreotide : a potential PET tracer for beta cell mass measurement2013

    • Author(s)
      Sako, T., Hasegawa, K., Nishimura, M., Kanayama, Y., Wada, Y., Hayashinaka, E., Cui, Y.L., Kataoka, Y., Senda, M. and Watanabe, Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 442(1-2) Pages: 79-84

    • DOI

      10.1016/j.bbrc.2013.11.001

    • Peer Reviewed
  • [Journal Article] Neuroinflammation in animal models of fatigue2013

    • Author(s)
      Kataoka, Y., Yamato, M., Miyashige, Y., Tamura, Y., Cui, Y.L
    • Journal Title

      Advances in Neuroimmune Biology

      Volume: 4 Pages: 237-244

    • Peer Reviewed
  • [Journal Article] Chronic degeneration of dorsal raphe serotonergic neurons modulates cortical spreading depression : A possible pathophysiology of migraine2013

    • Author(s)
      Cui, Y.L., Li, Q.H., Yamada, H., Watanabe, Y., Kataoka, Y
    • Journal Title

      J Neurosci Res

      Volume: 91 Pages: 737-744

    • DOI

      10.1002/jnr.23209

    • Peer Reviewed
  • [Presentation] Positron Emission Tomography (PET) Imaging Analysis for Investigating Gastrointestinal Movement and Exploring Antiemetic Reagent under Treatment of Osteoporosis Reagent Teriparatide2013

    • Author(s)
      Shingaki, T., Katayama, Y., Okauchi, T., Hayashinaka, E., Wada, Y., Kato, N., Kuroda, T., Cui, Y.L., Watanabe Y
    • Organizer
      2013 American Association of Pharmaceutical Scientists Annual Meeting
    • Place of Presentation
      San Antonio, USA
    • Year and Date
      20131111-13
  • [Presentation] MicroPETを用いた急性および慢性疼痛モデルラットにおける疼痛認知・伝達回路の解析2013

    • Author(s)
      崔翼龍, 佐古健生, 豊田浩士, 林中恵美, 和田康弘, 渡辺恭良, 片岡洋祐
    • Organizer
      第36回日本神経科学大会
    • Place of Presentation
      京都日本
    • Year and Date
      2013-06-21
  • [Presentation] 片頭痛モデル動物を用いたオピオイド受容体のPETイメージング2013

    • Author(s)
      崔翼龍、長田浩子、佐古健生、林中恵美、和田康弘、土居久志、渡辺恭良
    • Organizer
      第8回日本分子イメージング学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-05-30
  • [Presentation] Positron Emission Tomography (PET)による経鼻吸収評価系の確立2013

    • Author(s)
      新垣友隆、片山由美子、岡内隆、林中恵美、和田康弘、古林呂之、坂根稔康、崔翼龍、渡辺恭良
    • Organizer
      第8回日本分子イメージング学会
    • Place of Presentation
      横浜
    • Year and Date
      2013-05-30
  • [Presentation] 放射性ソマトスタチンアナログを用いた2型糖尿病モデルラットの膵内分泌細胞PETイメージング2012

    • Author(s)
      佐古健生、長谷川功紀、崔翼龍、和田康弘、林中恵美、片岡洋祐、千田道雄、渡辺恭良
    • Organizer
      第52回日本核医学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-10-10
  • [Presentation] MicroPETを用いた神経因性疼痛モデルラットの脳内疼痛認知・伝達回路の解析2012

    • Author(s)
      崔翼龍, 佐古健生, 奥山香里, 豊田浩士, 林中恵美, 和田康弘, 渡辺恭良, 片岡洋祐
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2012-09-19

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Published: 2015-06-25  

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