2013 Fiscal Year Final Research Report
Establishment of a novel method for brain activity dependent neuroimaging
| Project/Area Number |
24659574
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
CUI Yilong 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (60312229)
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| Co-Investigator(Kenkyū-buntansha) |
WADA Yasuhiro 独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, 副チームリーダー (40382197)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ＰＥＴ / 脳機能画像 / 神経活動 |
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| Research Abstract |
In order to establish a novel method for a neuronal activity-dependent neuroimaging analysis, a non-metal imaging device was fabricated to record the neurophysiological changes and PET scans simultaneously. The numerical model-based attenuation correction was implemented to correct for the lower counts induced by the device. The radioactivity in the blood quickly achieved a steady state after the intravenous injection of FDG combining bolus injection and continuous infusion, whereas it was continuously increased in the brain. Moreover, the electrical stimulation-related functional neuroimages were reconstructed by a trigger driven gating method in which every 5-sec PET list mode data were sorted into a gate sinogram according to a time-stamp driven by a trigger signal which was synchronized with the electrical stimulation.
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Research Products
(13 results)
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[Journal Article] Functional anatomy of gustation in the alert rat revealed by positron emission tomography2013
Author(s)
Kobayashi, M., Cui, Y.L.., Sako, T., Sasabe, T., Mizoguchi, N., Wada, Y., Kataoka, Y., Koshikawa, N
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Journal Title
J Neurosci Res
Volume: 91
Pages: 1363-1370
DOI
Peer Reviewed
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[Journal Article] Synthesis of an 11C-labeled antiprion GN8 derivative and evaluation of its brain uptake by positron emission tomography2013
Author(s)
Kimura, T., Sako, T., Siqin, Hosokawa-Muto, J., Cui, Y.L., Wada, Y., Kataoka, Y., Doi, H., Sakaguchi, S., Suzuki, M., Watanabe, Y., Kuwata, K
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Journal Title
ChemMedChem
Volume: 8
Pages: 1035-1039
DOI
Peer Reviewed
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[Journal Article] Evaluation of Oatp and Mrp2 Activities in Hepatobiliary Excretion using Newly Developed Positron Emission Tomography (PET) Tracer, [11C]Dehydropravastatin, in Rats2013
Author(s)
Shingaki, T., Takashima, T., Ijuin, R., Zhang, X., Onoue, T., Katayama, Y., Okauchi, T., Hayashinaka, E., Cui, Y.L., Wada, Y., Suzuki, M., Maeda, K., Kusuhara, H., Sugiyama, Y. and Watanabe, Y
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Journal Title
J Pharmacol Exp Ther
Volume: 347(1)
Pages: 193-202
DOI
Peer Reviewed
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[Journal Article] Positron emission tomography study on pancreatic somatostatin receptors in normal and diabetic rats with Ga-DOTA-octreotide : a potential PET tracer for beta cell mass measurement2013
Author(s)
Sako, T., Hasegawa, K., Nishimura, M., Kanayama, Y., Wada, Y., Hayashinaka, E., Cui, Y.L., Kataoka, Y., Senda, M. and Watanabe, Y
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Journal Title
Biochem Biophys Res Commun
Volume: 442(1-2)
Pages: 79-84
DOI
Peer Reviewed
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[Presentation] Positron Emission Tomography (PET) Imaging Analysis for Investigating Gastrointestinal Movement and Exploring Antiemetic Reagent under Treatment of Osteoporosis Reagent Teriparatide2013
Author(s)
Shingaki, T., Katayama, Y., Okauchi, T., Hayashinaka, E., Wada, Y., Kato, N., Kuroda, T., Cui, Y.L., Watanabe Y
Organizer
2013 American Association of Pharmaceutical Scientists Annual Meeting
Place of Presentation
San Antonio, USA
Year and Date
20131111-13
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