2012 Fiscal Year Final Research Report
In vivo tracking of transplanted cells using manganese-enhanced magnetic resonance imaging (MEMRI) and assessment of therapeutic effect to stroke model
| Project/Area Number |
24659576
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
ODAKA Kenichi 独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (20443062)
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| Project Period (FY) |
2012
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| Keywords | 磁気共鳴画像 / マンガン造影 / 細胞移植 / 脳虚血 / 再生医療 / 末梢血単核球 |
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| Research Abstract |
In-vivo tracking of transplanted Mn2+-labeled cells with Magnetic Resonance Imaging (MRI) was attempted to visualize the localization of migrated cells at high spatial resolution in stroke model rat and the long term regenerative therapeutic effects. Repeat measurement of MRI showed that transplanted peripheral mononuclear cells (MNCs) spread actively and concentrically in sham-operated rats. However, MNCs spread in ellipse and move faster to ischemic lesion in stroke model rats. In addition, stroke model rats revealed higher blood pressure in 3 weeks than in 2 weeks after cell transplantation. Mn2+-labeling and MRI are useful for cell selection, cell delivery, and assessment of therapeutic effect.
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[Presentation] IN-VIVO TRACKING OF TRANSPLANTED PERIPHERAL MONONUCLEAR CELLS LABELED WITH MANGANESE USING MAGNETIC RESONANCE IMAGING2012
Author(s)
Kenichi Odaka, Ichio Aoki, Kouichi Itoh, Junji Moriya, Kaoru Tateno, Tohru Minamino, Hiroyuki Tadokoro, Ichiro Shimoyama, Issei Komuro, Tsuneo Saga, Toshimitsu Fukumura
Organizer
International Society for Stem Cell Research 10th Annual Meeting
Place of Presentation
Yokohama、Japan
Year and Date
2012-06-15
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