Dynamic cardiomyoplasty using artificial muscle

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659581
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: General surgery
• Research Institution: Hirosaki University
• Principal Investigator: SUZUKI Yasuyuki 弘前大学, 医学(系)研究科(研究院), 准教授 (60344595)
• Co-Investigator(Kenkyū-buntansha): DAITOKU Kazuyuki 弘前大学, 医学研究科, 講師 (50374822)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 補助人工心臓 / 心不全

Outline of Final Research Achievements

Dynamic cardiomyoplasty using latissimus dorsi muscle was previously used to compensate for congestiveheart failure. Now, however, this method is not acceptable because the long-term result was not as expected owing to fatigue of the skeletal muscle. We made an artificial muscle like the latissimus dorsi using artificial rubber muscle and tested whether we could use this new muscle as a cardiac supporting device in swine models of dilated cardiomyopathy.
This cardiac supporting device's assistance of deteriorated heart showed significant improvement in hemodynamic data, such as cardiac output, stroke volume and ejection fraction. Although there are still needs for improvements in device component, direct cardiac assistance may be a good alternative to recent heart failure device therapies.

Free Research Field

胸部心臓血管外科