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2013 Fiscal Year Final Research Report

New strategy using diabetes therapeutic drug for the patients with vascular disease

Research Project

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Project/Area Number 24659586
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionNagoya University

Principal Investigator

KOMORI KIMIHIRO  名古屋大学, 医学(系)研究科(研究院), 教授 (40225587)

Co-Investigator(Kenkyū-buntansha) NARITA Hiroshi  名古屋大学, 医学部附属病院, 助教 (00528739)
KODAMA Akio  名古屋大学, 医学部附属病院, 病院助教 (10528748)
SUGIMOTO Masayuki  名古屋大学, 医学部附属病院, 病院助教 (00447814)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywords血管外科学
Research Abstract

(Background) We investigated whether metformin modulates the revascularization processes in vivo employing a hindlimb model of ischemia-induced angiogenesis. (Methods)Wild-type (WT) mice or eNOS deficient (eNOS-KO) mice were randomly divided into two groups. Mice were treated with or without metformine and were subjected to unilateral hind limb ischemia.(Results)WT mice (metformin group) showed accelerated limb perfusion following hindlimb ischemic surgery based upon laser Doppler measurements of blood flow and increased capillary density in ischemic muscle compared to non-treated mice. Metformin group significantly enhanced ischemia-induced increase in AMPK and eNOS phosphorylation levels in WT mice. In eNOS-KO mice, metformin significantly increased the phosphorylation of AMPK in ischemic tissue, but did not affect blood flow recovery in ischemic limb. (Conclusions)Metformin could promote revascularization in response to tissue ischemia via an AMPK/eNOS-dependent mechanism.

  • Research Products

    (25 results)

All 2014 2013 2012 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (11 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Metformin stimulates ischemia-induc ed revascularization through an eNO S dependent pathway in the ischemi c hindlimb mice model2014

    • Author(s)
      Takahashi N, Shibata R, Ouchi N, Su gimoto M, Murohara T, Komori K
    • Journal Title

      J Vasc Surg

      Volume: (in press)

    • Peer Reviewed
  • [Journal Article] Possible roles of 5-HT in vein graf t failure due to intimal hyperplasi a 5-HT, nitric oxide and vein graf t2014

    • Author(s)
      Kodama A, Itoh T, Komori K
    • Journal Title

      Surg Today

      Volume: 44 Pages: 213-8

    • DOI

      10.1007/s00595-013-0555-z

    • Peer Reviewed
  • [Journal Article] ole of Girdin in intimal hyperplasi a in vein grafts and efficacy of at elocollagen-mediated application of small interfering RNA for vein gra ft failure2013

    • Author(s)
      Miyachi H, Mii S, Enomoto A, Muraku mo Y, Kato T, Asai N, Komori K, Tak ahashi M
    • Journal Title

      J Vasc Surg

    • DOI

      10.1016/j.jvs.2013.06.080

    • Peer Reviewed
  • [Journal Article] Post Stress Perfusion Abnormalities Detected by Myocardial Perfusion S PECT Predict Long-Term Mortality af ter Elective Abdominal Aortic Aneur ysm Repair2013

    • Author(s)
      Inoue Y, Yoshikawa D, Ishii H, Isob e S, Kumagai S, Suzuki S, Okumura S ,Hayashi M, Matsubara T, Ohshima S, Banno H, Komori K, Kato K, Murohar a T
    • Journal Title

      Circulation Journal

      Volume: 77(5) Pages: 1229-34

    • Peer Reviewed
  • [Journal Article] Three-Dimensional Workstation is Us eful for Measuring the Correct Size of Abdominal Aortic Aneurysm Diame ters2013

    • Author(s)
      Ihara T, Komori K, Yamamoto K, Koba yashi M, Banno H, Kodama A
    • Journal Title

      Annals of Vascular Surgery

      Volume: 27(2) Pages: 54-61

    • DOI

      10.1016/j.avsg.2012.03.009

    • Peer Reviewed
  • [Journal Article] Ezetimibe reduces intimal hyperplas ia in rabbit jugular vein graft2012

    • Author(s)
      Maekawa T, Komori K, Morisaki K, It oh T
    • Journal Title

      J Vasc Surg

      Volume: 56(6) Pages: 1689-97

    • Peer Reviewed
  • [Journal Article] haracteristics of the actions by wh ich 5-hydroxytryptamine affects ele ctrical and mechanical activities i n rabbit jugular vein graft2012

    • Author(s)
      Maekawa T, Komori K, Kajikuri J, It oh T
    • Journal Title

      Br J Pharmacol

      Volume: 166(4) Pages: 1419-32

    • DOI

      10.1111/j.1476-5381.2012.01867.x

    • Peer Reviewed
  • [Journal Article] Cilostazol stimulates revascularisa tion in response to ischaemia via a n eNOS-dependent mechanism2012

    • Author(s)
      Hori A, Shibata R, Morisaki K, Muro hara T, Komori K
    • Journal Title

      Eur J Vasc Endovasc Surg

      Volume: 43(1) Pages: 62-5

    • DOI

      10.1016/j.ejvs.2011.07.015

    • Peer Reviewed
  • [Presentation] 破裂性腹部大動脈瘤治療の最前線2014

    • Author(s)
      古森公浩
    • Organizer
      第50回日本腹部救急医学会総会
    • Place of Presentation
      京王プラザホテル、東京都新宿区
    • Year and Date
      20140306-07
  • [Presentation] Can pre op myocardial perfusion SPE CT test predict late CV death after AAA repair2014

    • Author(s)
      Komori K
    • Organizer
      Controversies and Updates in Vascul ar Surgery (CACVS)
    • Place of Presentation
      Paris,France
    • Year and Date
      20140123-25
  • [Presentation] 血管病治療のパラダイムシフト―大動脈瘤と末梢動脈閉塞症―2014

    • Author(s)
      古森公浩
    • Organizer
      日本医工学治療学会第30回学術大会
    • Place of Presentation
      名鉄グランドホテル、名古屋市
    • Year and Date
      2014-03-21
  • [Presentation] Peripheral arterial disease(PAD)治療の最前線2013

    • Author(s)
      古森公浩
    • Organizer
      第54回日本脈管学会総会
    • Place of Presentation
      ステーションコンファレンス東京、東京都千代田区
    • Year and Date
      20131010-12
  • [Presentation] 血管病治療のパラダイムシフト2013

    • Author(s)
      古森公浩
    • Organizer
      第113回日本外科学会定期学術総会
    • Place of Presentation
      福岡国際会議場、福岡市
    • Year and Date
      20130411-13
  • [Presentation] 腎動脈再建を伴う腹部大動脈瘤手術2013

    • Author(s)
      古森公浩
    • Organizer
      第113回日本外科学会定期学術総会
    • Place of Presentation
      福岡国際会議場、福岡市
    • Year and Date
      20130411-13
  • [Presentation] 静脈血栓塞栓症2013

    • Author(s)
      古森公浩
    • Organizer
      第75回日本臨床外科学会総会
    • Place of Presentation
      名古屋国際会議場、名古屋市
    • Year and Date
      2013-11-21
  • [Presentation] 末梢動脈疾患の診療2013

    • Author(s)
      古森公浩
    • Organizer
      第4回脈管専門医教育セッション
    • Place of Presentation
      ステーションコンファレンス東京、東京都千代田区
    • Year and Date
      2013-10-11
  • [Presentation] Periphral Arterial Disease(PAD)の検査とマネジメント2013

    • Author(s)
      古森公浩
    • Organizer
      第6回DAIICHI-SANKYO SYMPOSIUM FOR THROMBOSIS UPDATE
    • Place of Presentation
      山形国際ホテル、山形市
    • Year and Date
      2013-05-31
  • [Presentation] 重症虚血肢に対する集学的治療2012

    • Author(s)
      古森公浩
    • Organizer
      第112回日本外科学会定期学術総会
    • Place of Presentation
      幕張メッセ千葉市
    • Year and Date
      20120412-14
  • [Presentation] Stentgraftの過去5年の変遷と治療成績2012

    • Author(s)
      古森公浩
    • Organizer
      第7回Japan Endovascular Symposium
    • Place of Presentation
      東京慈恵医科大学、東京都港区
    • Year and Date
      2012-08-30
  • [Book] エキスパートによる消化器外科静脈血栓塞栓症診療指針IV.診断CQ39どんなときにVTEを使うのか?2014

    • Author(s)
      古森公浩(森正樹、土岐祐一郎、左近賢人、池田正孝)
    • Total Pages
      189(140-142)
    • Publisher
      株式会社南江堂
  • [Book] 今日の治療指針末梢性動脈疾患(閉塞性動脈硬化症、バージャー病)2014

    • Author(s)
      古森公浩(他34名)
    • Total Pages
      2128(419-421)
    • Publisher
      株式会社医学書院
  • [Book] 腹部大動脈瘤に対するステントグラフト治療心臓外科Knack&Pitfalls大動脈外科の要点と盲点第2版2013

    • Author(s)
      古森公浩(髙本眞一)
    • Total Pages
      426(362-374)
    • Publisher
      株式会社文光堂
  • [Book] 第18章リンパ系標準外科学第13版2013

    • Author(s)
      古森公浩(加藤治文、畠山勝義、北野正剛、若林剛)
    • Total Pages
      743(667-670)
    • Publisher
      株式会社医学書院
  • [Book] 急性動脈閉塞症、急性上腸間膜動脈閉塞症、コルステロール塞栓今日の循環器疾患治療指針2013

    • Author(s)
      古森公浩(井上博、許俊鋭、檜垣實男、代田浩之、筒井裕之)
    • Total Pages
      968(731-737)
    • Publisher
      株式会社医学書院
  • [Remarks] 名古屋大学 大学院 医学系研究科 血管外科

    • URL

      http://www.vascsurg.jp/

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Published: 2015-06-25   Modified: 2015-07-02  

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