2013 Fiscal Year Final Research Report
The research of mechanisms between shear stress and caveola in the liver regeneration and liver injury
| Project/Area Number |
24659601
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Showa University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 肝再生 / 癌化 / 転移 / ずり応力 / caveolin-1 / PAI-1 / 脂肪肝 |
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| Research Abstract |
Last year, I changed my work location from Niigata Univ. to Showa Univ. Therefore, I could not perform the scheduled program. We intended to investigate comprehensively about a role of Caveolin-1 and PAI-1 in the liver. The clinicopathological analyses were made in the regenerative liver, steatotic liver, metastatic liver, and primary hepatocellular carcinoma and the mechanisms of regeneration, carcinogenesis, inflammation, and cancer metastasis were studied. Pilot study by immunological staining of the metastatic liver of colon cancer with caveolin-1, PAI-1, MT1-MMP, CD44 were performed. I could recognize the interesting findings that both the specimen of metastatic liver and primary colon cancer in Type 5 of colon cancer revealed the augmentation of PAI-1 staining.
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