Development of the monitoring system for the liver function in hepatectomy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659604
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Nagoya University
• Principal Investigator: NAGINO Masato 名古屋大学, 医学(系)研究科(研究院), 教授 (20237564)
• Co-Investigator(Kenkyū-buntansha): YOKOYAMA Yukihiro 名古屋大学, 医学部附属病院, 講師 (80378091) ; KOKURYO Toshio 名古屋大学, 医学系研究科, 特任講師 (60378023) ; IGAMI Tuyoshi 名古屋大学, 医学部附属病院, 病院講師 (50420378)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肝虚血・再灌流 / 一酸化窒素 / 肝障害

Outline of Final Research Achievements

We developed the NO sensor as a real-time monitoring system for the liver function. Intrahepatic NO levels increased and then reached a plateau approximately 15 min after starting ischemia during I/R (ischemia/reperfusion). The sinusoids after 5 min reperfusion were dilated compared with the sinusoids before ischemia during I/R. The phospho-eNOS expression increased during the first ischemia, and then the levels decreased during the subsequent repeating I/R; however, the iNOS expression gradually increased.
This study revealed an altered activation of the phospho-eNOS and iNOS over the course of repeated I/R.

Free Research Field

消化器外科学