Search of organ specific tumor makers by N-glycan expression

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659618
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Digestive surgery
• Research Institution: Kagoshima University
• Principal Investigator: NATSUGOE SHOJI 鹿児島大学, 医歯(薬)学総合研究科, 教授 (70237577)
• Co-Investigator(Kenkyū-buntansha): UENO Shinichi 鹿児島大学, 医歯学総合研究科, 特任教授 (40322317) ; MATAKI Yukou 鹿児島大学, 医学部・歯学部附属病院, 助教 (10444902) ; MAEMURA Kousei 鹿児島大学, 医学部・歯学部附属病院, 准教授 (30398292) ; SAKODA Masahiko 鹿児島大学, 医学部・歯学部附属病院, 助教 (40418851) ; UENOSONO Yoshikazu 鹿児島大学, 医歯(薬)学総合研究科, 特任准教授 (60398279) ; HASHIGUCHI Teruto 鹿児島大学, 医歯(薬)学総合研究科, 教授 (70250917)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 消化器癌 / N結合型糖鎖 / 食道癌 / 膵臓癌

Research Abstract

We analyzed the serum N-glycan by Profiling Solution in 63 esophageal cancer patients and 11 healthy volunteers. We selected 18 N-glycan by GlycoMod method. When performing by multivariate analysis in these N-glycan, 4 glycan had a significant difference. Three of these four N-glycan was in accord with structure of N-glycan which was previously extracted by MALDI-TOF-MS method. Thus new one N-glycan was found. These N-glycans are useful markers to detect esophageal cancer.
In pancreas cancer, we found 9 N-glycans which was stratified between esophageal cancer patients and healthy volunteers. In four of these 9 N-Glycans, significant difference was identified. We should collect many cases and analyze the useful markers for detection of pancreas cancer.

Research Products

• [Journal Article] Biomarkers for predicting the response of esophageal squamous cell carcinoma to neoadjuvant chemoradiation therapy (2014)
  • Author(s): Okumura H,Uchikado Y,Setoyama T,Matsumoto M,Owaki T,Ishigami S,Natsugoe S
  • Journal Title: Surg Today Volume: 44 Pages: 421-8
  • Peer Reviewed
• [Journal Article] Lymph node micrometastasis in gastrointestinal tract cancer-a clinical aspect (2013)
  • Author(s): Natsugoe S,Arigami T,Uenosono Y,Yanagita S,Nakajo A,Matsumoto M,Okumura H,Kijima Y,Sakoda M,Mataki Y,Uchikado Y,Mori S,Maemura K,Ishigami S
  • Journal Title: Int J Clin Oncol Volume: 18 Pages: 752-761
  • Peer Reviewed
• [Journal Article] Where will the concept of lymph node micrometastasis advance? (2013)
  • Author(s): Natsugoe S
  • Journal Title: Int J Clin Oncol Volume: 18 Pages: 751
  • Peer Reviewed
• [Journal Article] Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy (2013)
  • Author(s): Okumura H, Uchikado Y, Matsumoto M, Owaki T, Kita Y, Omoto I, Sasaki K, Sakurai T, Setoyama T, Nabeki B, Matsushita D, Ishigami S, Hiraki Y, Nakajo M, Natsugoe S
  • Journal Title: Int J Clin Oncol Volume: 18 Pages: 329-34
  • Peer Reviewed
• [Journal Article] Surgical treatment for esophageal cancer patients with myelodysplastic syndrome (2013)
  • Author(s): Okumura H,Uchikado Y,Matsumoto M,Owaki T,Kita Y,Setoyama T,Omoto I,Sasaki K,Megumi K,Minami K,Ishigami S,Natsugoe S
  • Journal Title: Esophagus Volume: 10 Pages: 149-152
  • Peer Reviewed
• [Journal Article] Clinical significance of circulating tumor cells in peripheral blood from patients with gastric cancer (2013)
  • Author(s): Uenosono Y,Arigami T,Kozono T,Yanagita S,Hagihara T,Haraguchi N,Matsushita D,Hirata M,Arima H,Funasako Y,Kijima Y,Nakajo A,Okumura H,Ishigami S,Hokita S,Ueno S,Natsugoe S
  • Journal Title: Cancer Volume: 119 Pages: 2398-2991
  • Peer Reviewed
• [Journal Article] A phase II study of oral S-1with concurrent radiotherapy followed by chemotherapy with S-1alone for locally advanced pancreatic cancer (2012)
  • Author(s): Shinchi H, Maemura K, Mataki Y, Kurahara H, Sakoda M, Ueno S, Hiraki Y, Nakajo M, Natsugoe S, Takao S
  • Journal Title: J Hepatobiliary Pancreat Sci Volume: 19 Pages: 152-8
  • Peer Reviewed
• [Journal Article] Endoscopic ultrasonography is useful for monitoring the tumor response of neoadjuvant chemoradiation therapy in esophageal squamous cell carcinoma (2012)
  • Author(s): Owaki T, Matsumoto M, Okumura H, Uchicado Y, Kita Y, Setoyama T, Sasaki K, Sakurai T, Omoto I, Shimada M, Sakamoto F, Yoshinaka H, Ishigami S, Ueno S, Natsugoe S
  • Journal Title: Am J Surg Volume: 203 Pages: 191-197
  • Peer Reviewed
• [Journal Article] Epithelial-mesenchymal transition and mesenchymal-epithelial transition via regulation of ZEB-1and ZEB-2expression in pancreatic cancer (2012)
  • Author(s): Kurahara H, Takao S, Maemura K, Mataki Y, Kuwahata T, Maeda K, Ding Q, Sakoda M, Iino S, Ishigami S, Ueno S, Shinchi H, Natsugoe S
  • Journal Title: J Surg Oncol Volume: 105 Pages: 655-661
  • Peer Reviewed
• [Presentation] Circulating Tumor Cells Predict Peritoneal Dissemination in Patients with Gastric Cancer (2013)
  • Author(s): Natsugoe S,Matsushita D,Uenosono Y,Arigami T,Haraguchi N,Yanagita S,Hagihara T,Ishigami S
  • Organizer: 9th International Symposium on Minimal Residual Cancer
  • Place of Presentation: Paris,France
  • Year and Date: 20130925-27
• [Presentation] Clinical Significance of Circulating Tumor Cells in Peripheral Blood from Patients with Gastric Cancer (2013)
  • Author(s): Uenosono Y,Arigami T,Yanagita S,Matsushita D,Hirahara S,Ishigami S,Natsugoe S
  • Organizer: 10th International Gastric Cancer Congress
  • Place of Presentation: Verona Italy
  • Year and Date: 2013-06-21
• [Presentation] Prognostic factors in esophageal squamous cell carcinoma patients treated with neoadjuvant chemoradiation therapy and determination of an appropriate strategy for their evaluation (2012)
  • Author(s): Okumura H, Uchikado Y, Matsumoto M, Owaki T, Kita Y, Omoto I, Sasaki K, Sakurai T, Setoyama T, Nabeki B, Matsushita D, Ishigami S, Suenaga T, Natsugoe S
  • Organizer: ISDE
  • Place of Presentation: Venice
  • Year and Date: 2012-10-16
• [Presentation] 食道癌診断に血清中N型糖鎖を利用した新規腫瘍マーカーとしての可能性 (2012)
  • Author(s): 内門泰斗,松本正隆,奥村浩,大脇哲洋,喜多芳昭,佐々木健,尾本至,橋口照人,石神純也,夏越祥次
  • Organizer: 第66回日本食道学会学術集会
  • Place of Presentation: 軽井沢(シンポジウム)
  • Year and Date: 2012-06-22
• [Presentation] Minimally Invasive Treatment for Adenocarcinoma of Esophago-Gastric Junction (2012)
  • Author(s): Natsugoe S, Uenosono Y, Arigami T, Okumura H, Matsumoto M, Uchikado Y, Kita Y, Owaki T, Aridome K, Hokita S, Ishigami S
  • Organizer: 10th International Conference of the Asian Clinical Oncology Society
  • Place of Presentation: Seoul(Symposium)
  • Year and Date: 2012-06-15
• [Presentation] The useful histological evaluation method for assessing prognosis of ESCC patients treated with neoadjuvant CRT (2012)
  • Author(s): Okumura H, Uchikado Y, Matsumoto M, Owaki T, Kita Y, Omoto I, Sasaki K, Sakurai T, Setoyama T, Nabeki B, Matsushita D, Ishigami S, Natsugoe S
  • Organizer: Oral presentation, 10th International Conference of the Asian Clinical Oncology Society
  • Place of Presentation: Seoul
  • Year and Date: 2012-06-13
• [Patent(Industrial Property Rights)] 消化器癌診断用マーカー,および消化器癌の検査方法 (2011)
  • Inventor(s): 夏越 祥次
  • Industrial Property Rights Holder: 鹿児島大学
  • Industrial Property Rights Type: 特願
  • Industrial Property Number: 2011-222353
  • Filing Date: 2011-10-06