2014 Fiscal Year Final Research Report
Relationship between microsatellite instability and microRNA in colon cancer
| Project/Area Number |
24659619
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
NAKAMURA IZUMI 福島県立医科大学, 医学部, 准教授 (80423804)
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| Co-Investigator(Kenkyū-buntansha) |
OHKI Shinji 福島県立医科大学, 器官制御外科, 准教授 (20381361)
TAKENOSHITA Seiichi 福島県立医科大学, 器官制御外科, 教授 (10167489)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | MSI / 大腸癌 / miRNA |
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| Outline of Final Research Achievements |
Mismatch repair-deficient colorectal cancers display widespread instability at DNA microsatellite sequences (MSI). But MSI has been reported to commonly occur at coding repeats, leading to alterations in the function of a number of genes encoding cancer-related proteins, nothing is known about the putative impact of this process on non-coding microRNAs.
We considered whether genetic mutation due to MSI changed the structure of miRNA hairpin loop by using thermodynamic free energy.Our results provide evidence that DNA repeats contained in human miRNA gene are relatively rare and preserved from mutations due to MSI.
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| Free Research Field |
腫瘍外科
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