Development of lung monitoring system for brain death donor

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659624
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Tohoku University
• Principal Investigator: NODA MASAFUMI 東北大学, 大学病院, 講師 (70400356)
• Co-Investigator(Kenkyū-buntansha): SADO Tetsu 東北大学, 大学病院, 助教 (20396485) ; OKADA Yoshinori 東北大学, 加齢医学研究所, 准教授 (90323104) ; KONDO Takashi 東北大学, 加齢医学研究所, 教授 (10195901)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 肺移植 / ドナー / 脳死 / 肺胞上皮 / ナトリウムチャネル / 急性拒絶反応

Research Abstract

Acute rejection after lung transplantation is lethal.We discovered a significant decrease in alveolar fluid clearance at 72hrs after animal lung transplantaion by acute rejection models. On the other hand discovered a no significant change in alveolar fluid clearance at 72hrs after animal lung transplantaion by non-acute rejection models. Monitoring of alveolar epithelial function after lung transplantaion is useful for detection by acute rejection.

Research Products

• [Journal Article] Contralateral pulmonary artery banding after single lobar lung transplantation (2014)
  • Author(s): Watanabe T, Okada Y, Adachi O, Sado T, Toyama H, Noda M, Hoshikawa Y, Oishi H, Sasahara Y, Saiki Y, Kondo T
  • Journal Title: Ann Thorac Surg Volume: 97(4) Pages: 1429-31
  • DOI: 10.1016/j.athoracsur.2013.07.030
  • Peer Reviewed
• [Journal Article] p190A RhoGAP is involved in EGFR pathways and promotes proliferation, invasion and migration in lung adenocarcinoma cells (2013)
  • Author(s): Notsuda H, Sakurada A, Endo C, Okada Y, Horii A, Shima H, Kondo T
  • Journal Title: Int J Oncol Volume: 43(5) Pages: 1569-77
  • DOI: 10.3892/ijo.2013.2096
  • Peer Reviewed
• [Journal Article] Awake video-thoracoscopic surgery for intractable pneumothorax in pregnancy by using a single portal plus puncture (2013)
  • Author(s): Onodera K, Noda M, Okada Y, Kondo T
  • Journal Title: Interact Cardiovasc Thorac Surg Volume: 17(2) Pages: 438-40
  • DOI: 10.1093/icvts/ivt205
  • Peer Reviewed
• [Journal Article] Reconstruction of pulmonary artery with donor aorta and autopericardium in lung transplantation (2013)
  • Author(s): Noda M, Okada Y, Saiki Y, Sado T, Hoshikawa Y, Endo C, Sakurada A, Maeda S, Oishi H, Kondo T
  • Journal Title: Ann Thorac Surg Volume: 96(1) Pages: e17-9
  • DOI: 10.1016/j.athoracsur.2013.01.029
  • Peer Reviewed
• [Journal Article] Registry of the Japanese society of lung and heart-lung transplantation : the official Japanese lung transplantation report 2012 (2013)
  • Author(s): Oto T, Okada Y, Bando T, Minami M, Shiraishi T, Nagayasu T, Chida M, Okumura M, Date H, Miyoshi S, Kondo T
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 61(4) Pages: 208-11
  • DOI: 10.1007/s11748-013-0215-7
  • Peer Reviewed
• [Journal Article] Successful management of intractable chylothorax in Gorham-Stout disease by awake thoracoscopic surgery (2013)
  • Author(s): Noda M, Endo C, Hoshikawa Y, Ishibashi N, Suzuki T, Okada Y, Kondo T
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 61(6) Pages: 356-8
  • DOI: 10.1007/s11748-012-0130-3
  • Peer Reviewed
• [Journal Article] 難治性気胸に対する再手術 (2013)
  • Author(s): 野田雅史, 近藤丘
  • Journal Title: 胸部外科 Volume: 66 Pages: 715-720
  • Peer Reviewed
• [Journal Article] Presented at the 64th Annual Scientific Meeting of the Japanese Association for thoracic surgery : wet-lab training for thoracic surgery at the laboratory animal facilities (2012)
  • Author(s): Noda M, Mizuma M, Maeda S, Sakurada A, Hoshikawa Y, Endo C, Okada Y, Unno M, Kasai N, Kondo T
  • Journal Title: Gen Thorac Cardiovasc Surg Volume: 60(11) Pages: 756-9
  • DOI: 10.1007/s11748-012-0134-z
  • Peer Reviewed
• [Journal Article] 1port&1puncture法による胸腔鏡下ブラ切除の経験 (2012)
  • Author(s): 小野寺賢, 野田雅史, 三友英紀, 前田寿美子, 岡田克典, 近藤丘
  • Journal Title: 日本呼吸器外科学会雑誌 Volume: 27巻2号 Pages: 187-190
  • Peer Reviewed
• [Presentation] 難治性呼吸器疾患の治療アプローチ-外科治療とインターベンション (2013)
  • Author(s): 野田雅史
  • Organizer: 第53回日本呼吸器病学会
  • Place of Presentation: 東京
  • Year and Date: 2013-04-20
• [Presentation] 脳死肺移植におけるCMV感染のマネージメント (2013)
  • Author(s): 新井川弘道
  • Organizer: 第29回日本肺及び心肺移植研究会
  • Place of Presentation: 千葉
  • Year and Date: 2013-01-26
• [Presentation] 脳死肺移植後の再手術の状況 (2013)
  • Author(s): 佐渡哲
  • Organizer: 第29回日本肺及び心肺移植研究会
  • Place of Presentation: 千葉
  • Year and Date: 2013-01-26
• [Presentation] 間葉系幹細胞投与による肺移植後急性拒絶反応抑制に関する実験的検討 (2013)
  • Author(s): 石橋直也
  • Organizer: 第29回日本肺及び心肺移植研究会
  • Place of Presentation: 千葉
  • Year and Date: 2013-01-26
• [Presentation] 肺リンパ脈管筋腫症に対する脳死肺移植の成績と問題点 (2012)
  • Author(s): 岡田克典
  • Organizer: 第48回日本移植学会総会
  • Year and Date: 2012-09-21
• [Presentation] 肺移植術後管理における持続的血液濾過透析導入に関する検討 (2012)
  • Author(s): 佐渡哲
  • Organizer: 第48回日本移植学会総会
  • Year and Date: 2012-09-21
• [Book] 呼吸器中外医学社LAMにおける脳死肺移植の現状, Annual Review (2013)
  • Author(s): 野田雅史, 岡田克典, 近藤丘
  • Total Pages: 294 (236-241)