Lung Regenerative Therapy Using Cell Sheets Releasing Cytokines for COPD Patients

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659629
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Thoracic surgery
• Research Institution: Osaka University
• Principal Investigator: MEINOSHIN Okumura 大阪大学, 医学(系)研究科(研究院), 教授 (40252647)
• Co-Investigator(Kenkyū-buntansha): MINAMI Masato 大阪大学, 医学部附属病院, 准教授 (10240847) ; INOUE Masayoshi 大阪大学, 医学系研究科, 准教授 (10379232) ; SAWABATA Noriyoshi 大阪大学, 医学系研究科, 准教授 (50403184) ; NAKAGIRI Tomoyuki 大阪大学, 医学系研究科, 招へい教員 (70528710) ; SHINTANI Yasushi 大阪大学, 医学系研究科, 講師 (90572983) ; KAWAMURA Tomohiro 大阪大学, 医学系研究科, 助教 (30528675)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肺再生医療 / 閉塞性肺疾患 / アディポネクチン / PGI2アナログ

Outline of Final Research Achievements

COPD is a major cause of chronic morbidity and mortality worldwide, and there is a need to develop more effective therapeutic strategies to replace specialized treatment such as lung transplantation. Adiponectin (APN) is a unique adipokine with multiple salutary effects such as antiapoptotic, anti-inflammatory, and anti-oxidative activities in numerous organs and cells and mice lacking APN spontaneously develop a COPD-like phenotype with extrapulmonary effects. Transplanted adipose tissue from wild type mice sttenuated COPD-like chnages in mice lacking APN. ONO-1301 is a synthetic prostacyclin analog characterized by chemically stable structure and enhances the secretion of adypocyte derived APN. These data suggested that APN is an intriguing candidate as a promotive agent for compensatory lung regeneration in COPD patients and prostacyclin analog enhanced alveolar cell proliferation, and induce lung regeneration through APN.

Free Research Field

肺再生医療