Pathogenesis of bleb formation in idiopathic pneumothorax

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659636
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Thoracic surgery
• Research Institution: Saga University
• Principal Investigator: TAKEDA Yuji 佐賀大学, 医学部, 助教 (20530182)
• Co-Investigator(Kenkyū-buntansha): AOKI Shigehisa 佐賀大学, 医学部, 准教授 (10448441) ; SAKURAGI Toru 佐賀大学, 医学部, 講師 (20315188)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: ブレブ形成 / 自然気胸

Research Abstract

Purpose: The Bleb, which can cause spontaneous pneumothorax development. We conducted a study in order to identify the presence of a specific pathogen in the formation of the Bleb. Method: From the lungs excised during spontaneous pneumothorax surgery, by extracting RNA and DNA, was subjected to gene search using a sensitive exhaustive search method pathogens.
Result: Such as TTV, HHV-6, HHV-7, EBV, parvovirus B19 were detected from Bleb part. But these viruses are detected from the normal lung tissue, except parvovirus B19. Relevance of bleb formation and these pathogens unknown at this time. Conclusion: Identification of specific pathogens were unable to Bleb tissue that could be the pathogenesis of pneumothorax.