2013 Fiscal Year Final Research Report
Development of completely autologous aortic valves by a novel concept of regenerative medicine
| Project/Area Number |
24659641
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Thoracic surgery
|
|---|
| Research Institution | National Cardiovascular Center Research Institute |
|---|
Principal Investigator |
TAKAMIZAWA Keiichi 独立行政法人国立循環器病研究センター, 研究所, 研究員 (10163312)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Yasuhide 独立行政法人国立循環器病研究センター, 研究所, 室長 (50250262)
|
|---|
| Project Period (FY) |
2012-04-01 – 2014-03-31
|
| Keywords | 心臓弁 / 再生医療 / 組織工学 / 移植 / 大動脈弁 / 自己組織 |
|---|
| Research Abstract |
A 3D printer, which can easily reproduce the 3D-shape and size of native heart valves, was used to produce the molds for a tri-leaflet, valved conduit with a sinus of Valsalva. Biovalves were obtained from completely autologous connective tissue, containing collagen and fibroblasts, within 2 months following the subcutaneous embedding of the molds. In vitro evaluation, using a pulsatile circulation circuit, showed excellent valvular function with a durability of at least 10 days. The Biovalves were implanted in goats through an apicoaortic bypass procedure. Smooth movement of the leaflets with minimal regurgitation were observed. After 1 month of implantation, smooth white leaflets were observed with minimal thrombus formation. Functional, autologous, 3D-shaped heart valves with clinical application potential were formed following in-body embedding of specially designed molds.
|
-
[Journal Article] In body tissue engineered aortic valve (Biovalve type VII) architecture based on 3D printer molding2014
Author(s)
Nakayama Y, Takewa Y, Sumikura H, Yamanami M, Matsui Y, Oie T, Kishimoto Y, Arakawa M, Ohmuma K, Kanda K, Tatsumi E
-
Journal Title
J Biomed Mater Res B Appl Biomater
Volume: (in press)
DOI
Peer Reviewed
-
-
-
-
-
[Journal Article] In vivo evaluation of an in-body, tissue-engeered, completely autologous valved conduit (biovalve type VI) as an aortic valve in a goat model2013
Author(s)
Takewa Y, Yamanami M, Kishimoto Y, Arakawa M, Kanda K, Matsui Y, Oie T, Ishibashi-Ueda H, Tajikawa T, ohba K, Yaku H, Taenaka Y, Tatsumi E, Nakayama Y
-
Journal Title
J Artif Organs
Volume: 16
Pages: 176-184
DOI
Peer Reviewed
-
-
-
-
[Presentation] 3Dプリンターによるバイオバルブ開発の可能性拡大2014
Author(s)
中山泰秀, 武輪能明, 上地正実, 神田計一, 川尻英長, 水野壮司, 船山麻理菜, 森脇健司, 逢坂真吾, 田地川勉, 大家智憲, 田中孝晴, 杉浦寿史, 巽英介
Organizer
第13回日本再生医療学会
Place of Presentation
京都国際会館
Year and Date
20140304-06
-
[Presentation] 人工弁の現状と今後の方向性 : 自己組織からなる心臓人工弁Biovalveの開発2013
Author(s)
武輪能明, 中山泰秀, 山南将志, 熱田祐一, 岸本諭, 伊達数馬, 住倉博仁, 大沼健太郎, 水野壮司, 神田圭一, 田地川勉, 田中孝晴, 妙中義之, 巽英介
Organizer
第51回日本人工臓器学会
Place of Presentation
パシフィコ横浜
Year and Date
20130926-29
-
-
-
-
[Presentation] In Vivo-Tissue Engineered Autologous Aortic Valved Conduits (BIOVALVEs type VII) : Preparation and Evaluation2012
Author(s)
Nakayama Y, Takewa Y, Sumikura H, Matsui Y, Yamanami M, Kishimoto Y, Arakawa M, Ohmuma K, Tajikawa T, Kansa K, Taenaka Y, Tatsumi E
Organizer
European Society for Artificial Organs
Place of Presentation
ドイツ、ロストック
Year and Date
20120926-29
-
-
-
-
-
-
