2014 Fiscal Year Final Research Report
Basic research of anti-malignant tumor effect using fullerene particles and neutron capture reaction.
| Project/Area Number |
24659643
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Fumiyo 筑波大学, 医学医療系, 助教 (30261811)
KUMADA Hiroaki 筑波大学, 医学医療系, 准教授 (30354913)
YAMAMOTO Tetsuya 筑波大学, 医学医療系, 講師 (30375505)
NAKAI Kei 筑波大学, 医学医療系, 講師 (50436284)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | フラーレン / ガドリニウム / 中性子捕捉療法 |
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| Outline of Final Research Achievements |
We aimed at securing sufficient concentrations of Gadolinium in neutron capture therapy (BNCT) by developing a new drug delivery system using fullerene. We have designed and developed a novel particle that consists of C82 fullerene including Gadolinium. The particles are designed for having EPR effect and adhesive property by sizing and surface modification. A trial to study the safety and intra-tumoral gadolinium distribution using micro-Particle Induced X-ray Emission were performed. Cells were cultured with Gd-DTPA containing medium, and neutron irradiations revealed the radiobiological effect of neutron capture effect.
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| Free Research Field |
脳神経外科
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