New antiangiogenic therapy for glioblastoma: photodynamic and synthetic peptide therapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24659645
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Cerebral neurosurgery
• Research Institution: University of Tsukuba
• Principal Investigator: TAKANO Shingo 筑波大学, 学内共同利用施設等, 病院講師 (50292553)
• Co-Investigator(Kenkyū-buntansha): UEBA Tetsuya 高知大学, 医学部, 教授 (00314203)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 血管新生 / 膠芽腫 / 合成ペプチド / FGF2 / FGF2受容体 / 脳梗塞

Outline of Final Research Achievements

As a specific inhibitor for angiogenic factor FGF2, we are interested in antisence homology box (AHB) in FGF2 receptor. Based on the computer analysis of FGF2 receptor, 13 synthetic peptides for AHB were designed. Human endothelial cell proliferation assay was determined with these peptides. Unexpectedly, some peptides demonstrated strong endothelial proliferation activity with elevated FGF2 signal transduction. Finally the angiogenic activity of the peptide was confirmed by other several assays. We propose AHB derived FGF2 receptor peptide is a candidate of angiogenic therapy for ischemic disease such as cerebral infarction.

Free Research Field

脳神経外科