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2013 Fiscal Year Final Research Report

In vivo optical imaging methods evaluating neurological diseases

Research Project

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Project/Area Number 24659651
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionOkayama University

Principal Investigator

ABE Koji  岡山大学, 医歯(薬)学総合研究科, 教授 (20212540)

Co-Investigator(Kenkyū-buntansha) IKEDA Yoshio  群馬大学, 医学研究科, 教授 (00282400)
Project Period (FY) 2012-04-01 – 2014-03-31
KeywordsIn vivo イメージング / 脳梗塞 / マトリックスメタロプロテアーゼ / 血栓溶解療法 / 出血性脳梗塞
Research Abstract

Matrix metalloproteinase in vivo optical imaging technique could provide a novel non-invasive and real-time detection method for acute ischemic injury, especially when tPA and free radical scavenger are used after a stroke.

  • Research Products

    (21 results)

All 2014 2013

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (10 results) Book (2 results)

  • [Journal Article] Reducing hemorrhagic complication by dabigatran via neurovascular protection after recanalization with tissue plasminogen activator in ischemic stroke of rat2014

    • Author(s)
      Kono S, Deguchi K, and Abe K
    • Journal Title

      J Neurosci Res

      Volume: 92 Pages: 46-53

    • DOI

      10.1002/jnr.23302

    • Peer Reviewed
  • [Journal Article] In vivo optical imaging correlates with improvement of cerebral ischemia treated by intravenous bone marrow stromal cells (BMSCs) and edaravone2013

    • Author(s)
      Tian F, Yamashita T, Deguchi K, Omote Y, Kawai H, Ohta Y, Abe K
    • Journal Title

      Neurol Res

      Volume: 35 Pages: 1051-1058

    • DOI

      10.1179/1743132813Y.0000000252

    • Peer Reviewed
  • [Journal Article] Combination benefit of amlodipine plus atorvastatin treatment on carotid atherosclerosis in Zucker metabolic rats2013

    • Author(s)
      Kawai H, Kurata T, and Abe K
    • Journal Title

      Neurol Res

      Volume: 35 Pages: 181-186

    • DOI

      10.1007/s12975-012-0205-6

    • Peer Reviewed
  • [Journal Article] Tissue plasminogen activator thrombolytic therapy for acute ischemic stroke in 4 hospital groups in Japan2013

    • Author(s)
      Kono S, Deguchi K, and Abe K
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 22 Pages: 190-196

    • DOI

      10.1016/j.jstrokecerebrovasdis.2011.07.016

    • Peer Reviewed
  • [Journal Article] Intravenous thrombolysis with neuroprotective therapy by edaravone for ischemic stroke patients older than 80 years of age2013

    • Author(s)
      Kono S, Deguchi K, and Abe K
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 22 Pages: 1175-1183

    • DOI

      10.1016/j.jstrokecerebrovasdis.2013.02.010

    • Peer Reviewed
  • [Journal Article] Cerebral embolic stroke after disappearing takotsubo cardiomyopathy2013

    • Author(s)
      Matsuzono K, Ikeda Y, Deguchi S, and Abe K
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 22 Pages: 682-683

    • DOI

      10.1016/j.jstrokecerebrovasdis

    • Peer Reviewed
  • [Journal Article] Synchronized Babinski and Chaddock signs preceded the MRI findings in a case of repetitive transient ischemic attack2013

    • Author(s)
      Matsuzono K, Yoshiki T, Ikeda Y, Abe K
    • Journal Title

      Intern Med

      Volume: 52 Pages: 2127-2129

    • URL

      https://www.jstage.jst.go.jp/article/internalmedicine/52/18/52_52.0190/_article

    • Peer Reviewed
  • [Journal Article] Acceleration of TDP43 and FUS/TLS protein expressions in the preconditioned hippocampus following repeated transient ischemia2013

    • Author(s)
      Sun M, Yamashita T, Shang J, Liu N, Deguchi K, Liu W, Ikeda Y, Feng J, and Abe K
    • Journal Title

      J Neurosci Res

      Volume: 92 Pages: 54-63

    • DOI

      10.1002/jnr.23301

    • Peer Reviewed
  • [Journal Article] Intravenous Tissue Plasminogen Activator Therapy for an Acute Ischemic Stroke Patient with Later Diagnosed Unilateral Moyamoya Syndrome2013

    • Author(s)
      Yokoyama S, Manabe Y, Fujii D, Ikeda-Sakai Y, Narai H, Omori N and Abe K
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 22 Pages: 1190-1192

    • DOI

      10.1016/j.jstrokecerebrovasdis.2012.06.011

    • Peer Reviewed
  • [Presentation] Clinical and Pathological Improvement in Stroke-Prone Spontaneous Hypertensive Rats Associated with Pleiotropic Effect of Cilostazol2013

    • Author(s)
      Omote Y, Deguchi K, Kurata T, Yamashita T, Ikeda Y, and Abe K
    • Organizer
      International TIA/ACVS Conference (TIA2013)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20131115-16
  • [Presentation] Synergistic benefit of combined amlodipine plus atorvastatin on neuronal damage after stroke in Zucker metabolic rat2013

    • Author(s)
      Omote Y, Kawai H, Deguchi K, Yamashita T, Kurata T, and Abe K
    • Organizer
      International TIA/ACVS Conference (TIA2013)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20131115-16
  • [Presentation] A case of recurrent vasospasm of the cervical ICA2013

    • Author(s)
      Sato K, Omote Y, Nakano Y, Takamiya M, Yamashita T, Kurata T, Deguchi K, and Abe K
    • Organizer
      International TIA/ACVS Conference (TIA2013)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      20131115-16
  • [Presentation] Neuroprotective Therapy by Edaravone with Intravenous tPA for Acute Ischemic Stroke in the Elderly Patients2013

    • Author(s)
      Kono S, Deguchi K, Yamashita T, Manabe Y, Takao Y, Kashihara K, Inoue S, Kiriyama H, and Abe K
    • Organizer
      The 6th Korea-Japan Joint Stroke Conference
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      20131005-06
  • [Presentation] Intravenous Thrombolysis with Neuroprotective Therapy by Edaravone for Ischemic Stroke Patients Older than 80 Years of Age2013

    • Author(s)
      Kono S, Deguchi K, Yamashita T, Manabe Y, Takao Y, Kashihara K, Inoue S, Kiriyama H, and Abe K
    • Organizer
      Asia Pacific Stroke Conference 2013
    • Place of Presentation
      Hong Kong, China
    • Year and Date
      20130830-0901
  • [Presentation] Prospective surveillance data of human prion disease in Chugoku and Shikoku region in Japan2013

    • Author(s)
      Sato K, Abe K
    • Organizer
      The 20th IAGG World Congress of the International Association of Gerontology and Geriatrics
    • Place of Presentation
      Soeul, Korea
    • Year and Date
      20130626-27
  • [Presentation] Modifying neurorepair and neuroregenerative factors with tPA and edaravone after transient middle cerebral artery occlusion in rat brain2013

    • Author(s)
      Deguchi K, Liu N, Liu W, Omote Y, Kono S, Yunoki T, Deguchi S, Yamashita T, and Abe K
    • Organizer
      Brain 2013
    • Place of Presentation
      Shanghai, China
    • Year and Date
      20130520-23
  • [Presentation] Direct reprogramming from human fibroblasts to hiN cells; A novel method preparing cell resource for stroke therapy2013

    • Author(s)
      Yamashita T, Abeliovich A, and Abe K
    • Organizer
      Brain 2013
    • Place of Presentation
      Shanghai, China
    • Year and Date
      20130520-23
  • [Presentation] tPA thrombolytic therapy for acute ischemic stroke in 4 hospital groups of Japan2013

    • Author(s)
      Kono S, Deguchi K, Morimoto N, Kurata T, Yamashita T, Manabe Y, Takao Y, Kashihara K, and Abe K
    • Organizer
      Brain 2013
    • Place of Presentation
      Shanghai, China
    • Year and Date
      20130520-23
  • [Presentation] Clinical and Pathological Improvement in Stroke-Prone Spontaneous Hypertensive Rats Related to Pleiotropic Effect of Cilostazol2013

    • Author(s)
      Omote Y, Deguchi K, Tian F, Kawai H, Kurata T, Yamashita T, Ohta Y, Abe K
    • Organizer
      Internationa Stroke Conference
    • Place of Presentation
      Honolulu, Hawaii, USA
    • Year and Date
      20130206-08
  • [Book] Edaravone therapy : From bench to bedside:Oxidative Stress in Applied Basic Research and Clinical Practice - Pediatric Disorders2013

    • Author(s)
      Yamashita T, and Abe K
    • Total Pages
      154-163
    • Publisher
      Springer
  • [Book] Cerebro-Spinal Blood Flow and its Regulation : Nuroanesthesia and Cerebro-Spinal Protection2013

    • Author(s)
      Yamashita T, Miyazaki K, and Abe K
    • Total Pages
      29-35
    • Publisher
      Springer

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Published: 2015-06-25  

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