2013 Fiscal Year Final Research Report
The dynamics of DNA damage response in glioblastoma-Toward the development of new therapy-
| Project/Area Number |
24659653
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HATA Nobuhiro 九州大学, 大学病院, 助教 (10596034)
AMANO Toshiyuki 九州大学, 大学病院, 助教 (70448413)
NAKAMIZO Akira 九州大学, 医学研究院, 講師 (80529800)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 脳腫瘍 |
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| Research Abstract |
Cellular DNA is exposed to various kinds of DNA damage inducers. To combat these DNA damage, normal cells have intrinsic DNA damage response (DDR) system to protect the cell from endogenous and exogenous DNA damage inducer. In this study , we demonstrated that ATM/Chk2 pathway is inactivated in glioblastoma tissue, indicating that ATM/Chk2 pathway functions as tumor suppressor in the process of gliomagenesis.
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