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2013 Fiscal Year Final Research Report

Development of novel methods for imaging of bone marrow utilizing fluorescence techniques and spatiotemporal analysis of bone metastasis

Research Project

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Project/Area Number 24659679
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionEhime University

Principal Investigator

HIKITA Atsuhiko  愛媛大学, 医学(系)研究科(研究院), 准教授 (60443397)

Project Period (FY) 2012-04-01 – 2014-03-31
Keywords骨・軟部腫瘍学
Research Abstract

To elucidate the molecular mechanisms of interaction between cancer cells and microenvironments which determine the osteolytic/ osteogenic tendencies of bone metastases of cancer, series of experiments were performed to establish an in vivo imaging system by which 4 kind of cells, cancer cells, osteoclasts, osteoblasts and osteocytes in bone marrow can be analyzed simultaneously at multiple time points. Cancer cells expressing fluorescent proteins were implanted to mice and bone metastasis system of osteolytic prostate cancer was established. In vivo fluorescence imaging for osteoclast was also performed.

  • Research Products

    (4 results)

All 2013 2012

All Journal Article (3 results) Presentation (1 results)

  • [Journal Article] 骨転移微小環境の可視化と治療法開発2012

    • Author(s)
      疋田温彦、今村健志
    • Journal Title

      医学のあゆみ

      Volume: 241巻 Pages: 460-463

  • [Journal Article] がん細胞とがん微小環境のin vivoイメージング2012

    • Author(s)
      疋田温彦
    • Journal Title

      病理と臨床

      Volume: 30巻 Pages: 719-724

  • [Journal Article] 骨髄微小環境における癌細胞のin vivoイメージング2012

    • Author(s)
      疋田温彦、大嶋佑介、今村健志
    • Journal Title

      医学のあゆみ

      Volume: 242巻 Pages: 735-740

  • [Presentation] 骨髄内がん細胞の蛍光イメージング2013

    • Author(s)
      疋田温彦、今村健志、大嶋佑介
    • Organizer
      第33回日本骨形態計測学会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2013-07-05

URL: 

Published: 2015-06-25  

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