2013 Fiscal Year Final Research Report
Physiological function of hydrogen sulfide in osteoblasts.
| Project/Area Number |
24659686
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 骨代謝 / ガスバイオロジー |
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| Research Abstract |
Hydrogen sulfide has been recognized as a gaseous mediator with a variety of physiological functions. However, its role in the control of skeletal function is unknown. Hydrogen sulfide can be physiologically generated by enzymes, cystathionine beta-synthase (CBS). To define the physiological function of hydrogen sulfide in the skeletal tissue, we performed functional analysis of bone metabolism in CBS knockout mice. The knockout mice showed significant growth retardation and various skeletal disorders. These results suggest that hydrogen sulfide is essential for normal bone metabolism.
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Research Products
(5 results)
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[Journal Article] Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis2012
Author(s)
Yoshikazu Hirose, Eiko Saijou, Yasuyoshi Sugano, Fumitaka Takeshita, Satoshi Nishimura, Hidenori Nonaka, Yen-Rong Chen, Keisuke Sekine, Taketomo Kido, Takashi Nakamura, Shigeaki Kato, Toru Kanke, Koji Nakamura, Ryozo Nagai, Takahiro Ochiya, Atsushi Miyajima
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Journal Title
Proceedings of National Academy of Science U S A
Volume: 109(11)
Pages: 4263-4268
DOI
Peer Reviewed
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