2013 Fiscal Year Final Research Report
Pharmacological mechanisms of locus coeruleus activation -recruitment of descending inhibition for treatment of neuropathic pain-
| Project/Area Number |
24659691
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gunma University |
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Principal Investigator |
OBATA Hideaki 群馬大学, 医学(系)研究科(研究院), 准教授 (20302482)
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| Co-Investigator(Renkei-kenkyūsha) |
MIEDA Rie 群馬大学, 医学部附属病院, 助教 (10400772)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | ノルアドレナリン / 脊髄 / α2受容体 / ラット |
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| Research Abstract |
Pregabalin and gabapentin are often used as first-line drugs in the treatment of neuropathic pain. Previous studies suggest that these drugs activate descending inhibitory systems. In the present project, using rats, we observed that systemic administration of pregabalin increased noradrenaline level in the dorsal horn of the lumbar spinal cord through activation of locus coeruleus. The increased noradrenaline inhibit not only neuropathic pain but also acute pain via spinal alpha-2 adrenoceptors. The mechanisms by which pregabalin activates locus coeruleus are still under active investigation.
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Research Products
(29 results)
