The development of objective evaluation of pain

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659696
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Osaka University
• Principal Investigator: MASHIMO Takashi 大阪大学, その他部局等, 名誉教授 (10110785)
• Co-Investigator(Kenkyū-buntansha): NAKAE Aya 大阪大学, 大学院医学系研究科, 特任准教授 (60379170)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: 痛みの客観的評価 / 脳波 / 末梢循環 / 誘発電位 / パルスオキシメーター

Research Abstract

When we evaluate our patients' amount of pain, we have referred their self-reported pain until now.Of course we treat their pain using decided some of analgesics, but we have not enough considered of individual differences in pain sensitivity and in threshold of side effects. To resolve this situation, we need to develop the objective measurement tool for the amount of pain. Towards this end, we conducted a study to develop the algorithm of objective evaluation of pain using physiological indices of human beings.
Firstly, we revealed the feature of physiological parameter especially about the difference between age and sex using EEG and pulse-oxmeter. The algorithm which extracted from EEG data is currently being prepared to do patent application. Moreover, we revealed that the perfusion index, which is an index reflecting the peripheral circulation, might be a good indicator when we evaluate the pain by the stimulation to the extent that the pulse rate did not change.

Research Products

• [Journal Article] Age-related and sex-related changes in perfusion index in response to noxious electrical stimulation in healthy subjects (2014)
  • Author(s): Nishimura T, Nakae A, Shibata M, Mashimo T, Fujino Y
  • Journal Title: J Pain Res Volume: 10(7) Pages: 91-7
• [Journal Article] Pain modulation by negative and positive emotional sounds (2013)
  • Author(s): Aya Nakae, Thomas Hermann, Takashi Ikeda, Teruko Sakurai, Tomonori Adachi, Hiroshi Ito, Toshiki Nishimura, Masahiko Shibata, Mariko Osaka, Takashi Mashimo
  • Journal Title: Proceedings of 4^<th> International Congress of Neuropathic pain Pages: 43-48
• [Presentation] Correlation between changes of brain activity and subjective pain intensity under sedation ~Contact heat evoked potential study~ (2014)
  • Author(s): Aya Nakae, Satoshi Hagihira, Hiroshi Ito, Piyasak Vitrabrananont, Kan Hongling, Yuji Fujino
  • Organizer: Euroanaestheisa 2014
  • Place of Presentation: Stockholm, poster
  • Year and Date: 20140530-0603
• [Presentation] 鎮静下における痛み刺激に対する生理反応の違い。～プロポフォールとミダゾラムの比較～ (2014)
  • Author(s): 伊藤寛、中江文、康、紅玲、萩平哲、藤野裕士
  • Organizer: 第7回麻酔科痛みのメカニズムを語る会
  • Place of Presentation: 東京
  • Year and Date: 20140304-05
• [Presentation] Different effect of experimental electrical pain on autonomic nervous system derived from peripheral perfusion index in healthy volunteers (2013)
  • Author(s): Aya Nakae, Toshiki Nishimura, Masahiko Shibata, Takashi Mashimo, Yuji Fujino
  • Organizer: 8th Congress of the European Federation of IASP chapters-PAIN IN EUROPE VIII
  • Place of Presentation: Florence, selected poster
  • Year and Date: 20131009-12
• [Presentation] C繊維の誘発電位の潜時に関する検討 (2013)
  • Author(s): 伊藤寛、康紅玲、中江文、柴田政彦、藤野裕士
  • Organizer: 第35回日本疼痛学会
  • Place of Presentation: 大宮
  • Year and Date: 20130712-13
• [Presentation] Pain and executive function. International Symposium on Cognitive Neuroscience Robotics (2013)
  • Author(s): Aya Nakae
  • Organizer: Knowledge Theater
  • Place of Presentation: Osaka
  • Year and Date: 2013-08-22
  • Invited
• [Presentation] Pain and attention in elderly volunteers. International Symposium on Cognitive Neuroscience Robotics (2013)
  • Author(s): Aya Nakae
  • Organizer: Paul G. Allen Center for CSE
  • Place of Presentation: University of Washington, Seattle
  • Year and Date: 2013-02-01
  • Invited
• [Presentation] 実験的痛みと末梢循環の変化 (2012)
  • Author(s): 西村俊樹、中江文、柴田政彦、眞下節
  • Organizer: 第34回日本疼痛学会
  • Place of Presentation: 熊本
  • Year and Date: 20120720-21
• [Presentation] Contact heat evoked potentials (CHEPs) in healthy subjects-no laterality effect
  • Author(s): Yelena Granovsky, Praveen Anand, Aya Nakae, Osvaldo Nascimento, Benn Smith, Josep Valls-Sole, David Yarnitsky
  • Organizer: 30^<th> International Congress of Clinical Neurophysiology
  • Place of Presentation: poster
  • Year and Date: 00000519-23
• [Presentation] The Influence of Age and Height on Latency and Amplitude of Contact Heat Evoked Potentials(CHEPS) (0)
  • Author(s): Benn Smith, Yelena Granovsky, Osvaldo Nascimento, Josep Valls-Sole, Aya Nakae, David Yarnitsky, Huson L, Praveen Anand
  • Organizer: American Neurological Association's 2013 Annual Meeting
  • Place of Presentation: New Orleans, LA, poster
  • Year and Date: 00001015
• [Presentation] Pain Modulation by Negative and Positive Emotional Sounds (0)
  • Author(s): Aya Nakae A, Thomas Hermann, Takashi Ikeda, Teruko Sakurai, Tomonori Adachi, Hiroshi Ito, Toshiki Nishimura, Masahiko Shibata, Mariko Osaka, Takashi Mashimo
  • Organizer: 4th INTERNATIONAL CONGRESS ON NEUROPATHIC PAIN(IASP)
  • Place of Presentation: Toronto, Canada, poster
  • Year and Date: 00000524
• [Book] Mechanisms of Pain". Text book"Cognitive Neuroscience of Robotics" (2014)
  • Author(s): Aya Nakae
  • Total Pages: Chap.7
  • Publisher: (in press)