Usefulness of volatile biomarkers in breath for perioperative management

2013 Fiscal Year Final Research Report

• Project/Area Number: 24659700
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Single-year Grants
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: Kagoshima University
• Principal Investigator: MATSUNAGA Akira 鹿児島大学, 医歯(薬)学総合研究科, 准教授 (70284883)
• Co-Investigator(Kenkyū-buntansha): SHIMSANOE Kengo 九州大学, 総合理工学部, 教授 (10274531)
• Co-Investigator(Renkei-kenkyūsha): KAKIHANA Yasuyuki 鹿児島大学, 医歯学総合研究科, 教授 (20264426)
• Project Period (FY): 2012-04-01 – 2014-03-31
• Keywords: ガスセンサ / 揮発性有機化合物(ＶＯＣｓ） / 患者評価

Research Abstract

The aim of this study was to identify the useful volatile organic compounds (VOCs) in breath for evaluating perioperative patients, and to develop the accurate gas sensor for measuring the concentration of the VOCs. Changes in VOCs in breath were analyzed by gas chromatography in patients who underwent highly invasive operations. However, the useful volatile biomarkers were not identified.
Water vapor content and lowing catalytic activity decreased the accuracy of gas sensor for measuring VOCs.

Research Products

• [Journal Article] Nanoparticle cluster gas sensor : controlled clustering of SnO_2 nanoparticles for highly sensitive toluene detection (2014)
  • Author(s): Suematsu K, Shin Y, Hua Z, Yoshida K, Yuasa M, Kida T, Shimanoe K
  • Journal Title: ACS Appl Mater Interfaces Volume: 6 Pages: 5319-26
  • Peer Reviewed
• [Journal Article] Perfusion index as a possible predictor for postanesthetic shivering (2014)
  • Author(s): Kuroki C, Godai K, Hasegawa-Moriyama M, Kuniyoshi T, Matsunaga A, Kanmura Y, Kuwaki T
  • Journal Title: J Anesth Volume: 28 Pages: 19-25
  • Peer Reviewed
• [Journal Article] Recombinant Thrombomodulin Protects Mice against Histone-Induced Lethal Thromboembolism (2013)
  • Author(s): Nakahara M, Ito T, Kawahara KI, Yamamoto M, Nagasato T, Shrestha B, Yamada S, Miyauchi T, Higuchi K, Takenaka T, Yasuda T, Matsunaga A, Kakihana Y, Hashiguchi T, Kanmura Y, Maruyama I
  • Journal Title: PLoS One Volume: 30:8 Pages: 75961
  • Peer Reviewed
• [Journal Article] Remifentanil temporarily improves renal function in adult patients with chronic kidney disease undergoing orthopedic surgery (2013)
  • Author(s): Terashi T, Takehara A, Kuniyoshi T, Matsunaga A, Kawasaki K, Kanmura Y
  • Journal Title: J Anesth Volume: 27 Pages: 340-5
  • Peer Reviewed
• [Journal Article] Increased carboxyhemoglobin level during liver resection with inflow occlusion (2013)
  • Author(s): Godai K, Hasegawa-Moriyama M, Kuniyoshi T, Matsunaga A, Kanmura Y
  • Journal Title: J Anesth Volume: 27 Pages: 306-8
  • Peer Reviewed
• [Presentation] 多波長パルスオキシメータによるメトヘモグロビン血症患者モニタリング (2013)
  • Author(s): 松永明、磯脇純和、上村裕一
  • Organizer: 第35回日本手術医学会総会
  • Place of Presentation: 横浜
  • Year and Date: 20130000
• [Presentation] 麻酔科領域におけるタブレットツールの応用 (2012)
  • Author(s): 松永明、磯脇純和、上村裕一
  • Organizer: 第34回日本手術医学会総会
  • Place of Presentation: 東京
  • Year and Date: 20120000