2014 Fiscal Year Final Research Report
Development of novel molecular targeting therapies for ectopic pregnancy using its model mice
| Project/Area Number |
24659722
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 異所性妊娠 / モデル動物 / 分子標的治療 |
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| Outline of Final Research Achievements |
Although methotrexate has been widely used for medical treatment of ectopic pregnancy, the development of more effective medical treatment with less adverse effects is anticipated. In this study, we performed DNA microarray analyses to find cell signaling pathway important for growth of villous tissues. Using villous tissue explants and an animal model for ectopic pregnancy, we evaluated their potential as candidates for molecular targeting therapy. We could find 3 targets with high potentials for development of novel medical therapies for ectopic pregnancy.
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| Free Research Field |
産婦人科
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