2013 Fiscal Year Final Research Report
Identification of endometrial cancer stem cell markers
| Project/Area Number |
24659736
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyushu University |
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Principal Investigator |
KATO Kiyoko 九州大学, 医学(系)研究科(研究院), 教授 (10253527)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 子宮体癌 / 癌幹細胞 |
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| Research Abstract |
We analyzed the association with dbpC/contrin(dbpC) and the character of endometrial cancer stem cells .We designed and constructed a cytomegarovirus vector containing dbpC cDNA, and transfected it into Ishikawa(IK) cells, an endometrial cancer cell line. The expression of ALDH1 was increased in IK-dbpC cells, compared to mock cells,and the ratio of SP cells were more than 10-fold in IK-dbpC cells compared to mock cells . Downreguration of dbpC expression was remarkably reduced the ALDH1 expression and the rate of SP cells, compared to negative control. Microarray analysis showed that one of the cancer/testis antigens was up-regulated in IK-dbpC cells compared with mock cells.
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[Journal Article] The inhibitory effect of salinomycin on the proliferation, migration and invasion of human endometrial cancer stem-like cells2013
Author(s)
Kusunoki S, Kato K, Tabu K, Inagaki T, Okabe H, Kaneda H, Suga S, Terao Y, Taga T,Takeda S
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Journal Title
Gynecol Oncol
Volume: 129(3)
Pages: 598-605
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