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2013 Fiscal Year Final Research Report

Regulatory roles of Toll like receptor signaling in corneal endothelial cells

Research Project

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Project/Area Number 24659760
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Ophthalmology
Research InstitutionTottori University

Principal Investigator

RYOKO ISHIKURA  鳥取大学, 医学部附属病院, 助教 (00335530)

Co-Investigator(Kenkyū-buntansha) MIYAZAKI Dai  鳥取大学, 医学部附属病院, 講師 (30346358)
INOUE Yoshitsugu  鳥取大学, 医学部, 教授 (10213183)
Project Period (FY) 2012-04-01 – 2014-03-31
Keywords角膜内皮
Research Abstract

Transcriptome of human corneal endothelial cells after HSV-1 infection was characterized by interferon response and pattern recognition receptor response. TLR9 stimulated by CpG DNA or viral infection induced Indoleamine 2,3-deoxygenase 1 (IDO1), which contribute to activation of regulatory T cells, which dampens inflammatory responses of acquired immune system for protection of corneal endothelial cells. Receptor of Advanced glycosylation end products was also induced by viral infection, and was suggested to be involved in recognition of damage associated molecule by TLR9.

  • Research Products

    (13 results)

All 2014 2013 2012

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results)

  • [Journal Article] Therapeutic effects of 0.1% tacrolimus eye drops for refractory allergic ocular diseases with proliferative lesion or corneal involvement2014

    • Author(s)
      Fukushima A, Ohashi Y, Ebihara N, Uchio E, Okamoto S, Kumagai N, Shoji J, Takamura E, Nakagawa Y, Namba K, Fujishima H, Miyazaki D
    • Journal Title

      Br J Ophthalmol

      Volume: (掲載予定)

    • DOI

      10.1136/bjophthalmol-2013-304453

    • Peer Reviewed
  • [Journal Article] Relationship between the number of cytomegalovirus in anterior chamber and severity of anterior segment inflammation2013

    • Author(s)
      Kandori M, Miyazaki D, Yakura K, Komatsu N, Touge C, Ishikura R, Inoue Y
    • Journal Title

      Jpn J Ophthalmol

      Volume: 57巻 Pages: 497-502

    • DOI

      10.1007/s10384-013-0268-2

    • Peer Reviewed
  • [Journal Article] Pharmacologic inhibition of IκB kinase activates immediate hypersensitivity reactions in mice2013

    • Author(s)
      Miyazaki D, Mihara S, Inata K, Sasaki S, Tominaga T, Yakura K, Ishida W, Fukushima A, Inoue Y
    • Journal Title

      Am J Pathol

      Volume: 183巻 Pages: 96-107

    • DOI

      10.1016/j.ajpath.2013.04.006

    • Peer Reviewed
  • [Journal Article] Associations of IL-23 with polypoidal choroidal vasculopathy2012

    • Author(s)
      Sasaki S, Miyazaki D, Miyake K, Terasaka Y, Kaneda S, Ikeda Y, Funakoshi T, Baba T, Yamasaki A, Inoue Y
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 53巻 Pages: 3414-30

    • DOI

      10.1167/iovs.11-7913

    • Peer Reviewed
  • [Journal Article] Assessment of real-time polymerase chain reaction detection of Acanthamoeba and prognosis determinants of Acanthamoeba keratitis2012

    • Author(s)
      Ikeda Y, Miyazaki D, Yakura K, Kawaguchi A, Ishikura R, Inoue Y, Mito T, Shiraishi A, Ohashi Y, Higaki S, Itahashi M, Fukuda M, Shimomura Y, Yagita K
    • Journal Title

      Ophthalmology

      Volume: 119巻 Pages: 111-9

    • DOI

      10.1016/j-ophtha.2011.12.023

    • Peer Reviewed
  • [Journal Article] Blood level of tacrolimus in patients with severe allergic conjunctivitis treated by 0.1% tacrolimus ophthalmic suspension2012

    • Author(s)
      Ebihara N, Ohashi Y, Fujishima H, Fukushima A, Nakagawa Y, Namba K, Okamoto S, Shoji J, Takamura E, Uchio E, Miyazaki D
    • Journal Title

      Allergol Int

      Volume: 61巻 Pages: 275-82

    • DOI

      10.2332/allergolint.11-OA-0349

    • Peer Reviewed
  • [Presentation] 角膜内皮細胞の炎症応答におけるRAGE(終末糖化産物受容体)の役割2014

    • Author(s)
      神鳥美智子
    • Organizer
      第38回日本角膜学会総会
    • Place of Presentation
      沖縄コンベンションセンター
    • Year and Date
      20140130-0201
  • [Presentation] サイトメガロウイルス感染に対する角膜内皮の分子応答2013

    • Author(s)
      宮崎大
    • Organizer
      第50回眼感染症学会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2013-07-13
  • [Presentation] サイトメガロウイルス感染に対する角膜内皮の分子応答2013

    • Author(s)
      宮崎大
    • Organizer
      第28回ヘルペスウイルス研究会
    • Place of Presentation
      兵庫県立淡路夢舞台国際会議場
    • Year and Date
      2013-05-31
  • [Presentation] ヘルペスウイルス内皮感染の分子機構2013

    • Author(s)
      宮崎大
    • Organizer
      第117回日本眼科学会総会シンポジウム
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2013-04-04
  • [Presentation] アマンタジンにより角膜内皮障害を生じた2例2012

    • Author(s)
      石倉涼子
    • Organizer
      第66回日本臨床眼科学会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都
    • Year and Date
      20121025-28
  • [Presentation] 前眼部炎症疾患における前房内サイトメガロウイルスDNAのロジスティック解析2012

    • Author(s)
      神鳥美智子
    • Organizer
      第66回日本臨床眼科学会
    • Place of Presentation
      国立京都国際会館・グランドプリンスホテル京都
    • Year and Date
      20121025-28
  • [Presentation] アカントアメーバ角膜炎における予後予測因子の多変量解析2012

    • Author(s)
      宮崎大
    • Organizer
      第57回山陰眼科集談会・第86回鳥取大学眼科研究会
    • Place of Presentation
      米子全日空ホテル
    • Year and Date
      2012-05-13

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Published: 2015-06-25  

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