2013 Fiscal Year Final Research Report
Regulatory roles of Toll like receptor signaling in corneal endothelial cells
| Project/Area Number |
24659760
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Tottori University |
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Principal Investigator |
RYOKO ISHIKURA 鳥取大学, 医学部附属病院, 助教 (00335530)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAZAKI Dai 鳥取大学, 医学部附属病院, 講師 (30346358)
INOUE Yoshitsugu 鳥取大学, 医学部, 教授 (10213183)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 角膜内皮 |
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| Research Abstract |
Transcriptome of human corneal endothelial cells after HSV-1 infection was characterized by interferon response and pattern recognition receptor response. TLR9 stimulated by CpG DNA or viral infection induced Indoleamine 2,3-deoxygenase 1 (IDO1), which contribute to activation of regulatory T cells, which dampens inflammatory responses of acquired immune system for protection of corneal endothelial cells. Receptor of Advanced glycosylation end products was also induced by viral infection, and was suggested to be involved in recognition of damage associated molecule by TLR9.
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Research Products
(13 results)
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[Journal Article] Therapeutic effects of 0.1% tacrolimus eye drops for refractory allergic ocular diseases with proliferative lesion or corneal involvement2014
Author(s)
Fukushima A, Ohashi Y, Ebihara N, Uchio E, Okamoto S, Kumagai N, Shoji J, Takamura E, Nakagawa Y, Namba K, Fujishima H, Miyazaki D
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Journal Title
Br J Ophthalmol
Volume: (掲載予定)
DOI
Peer Reviewed
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[Journal Article] Assessment of real-time polymerase chain reaction detection of Acanthamoeba and prognosis determinants of Acanthamoeba keratitis2012
Author(s)
Ikeda Y, Miyazaki D, Yakura K, Kawaguchi A, Ishikura R, Inoue Y, Mito T, Shiraishi A, Ohashi Y, Higaki S, Itahashi M, Fukuda M, Shimomura Y, Yagita K
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Journal Title
Ophthalmology
Volume: 119巻
Pages: 111-9
DOI
Peer Reviewed
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[Journal Article] Blood level of tacrolimus in patients with severe allergic conjunctivitis treated by 0.1% tacrolimus ophthalmic suspension2012
Author(s)
Ebihara N, Ohashi Y, Fujishima H, Fukushima A, Nakagawa Y, Namba K, Okamoto S, Shoji J, Takamura E, Uchio E, Miyazaki D
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Journal Title
Allergol Int
Volume: 61巻
Pages: 275-82
DOI
Peer Reviewed
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