2013 Fiscal Year Final Research Report
The relation between chronic inflammatory reaction and photoreceptor cell death in retinitis pigmentosa
| Project/Area Number |
24659763
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MURAKAMI Yusuke 九州大学, 医学研究科, 研究員 (50634995)
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| Project Period (FY) |
2012-04-01 – 2014-03-31
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| Keywords | 網膜色素変性 / 視細胞死 / 慢性炎症 / 抗酸化剤 |
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| Research Abstract |
We demonstrated sequential events involving increased expression of proinflammatory cytokines and chemokines, activation of microglia, and photoreceptor apoptosis during retinal degeneration of rd10 mice. Furthermore, antioxidant treatment with N-acetylcysteine prevented the photoreceptor cell death along with suppression of inflammatory factors and microglial activation. Sustained chronic inflammatory reaction may contribute to the pathogenesis of retinal degeneration in rd10 mice, suggesting interventions for ocular inflammatory reaction using antioxidants as a potential treatment for patients with RP.
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